Changes in purinergic responses of the rabbit isolated central ear artery after chronic electrical stimulation in vivo

1 The effect of chronic (4–16 days) electrical stimulation (5 Hz, 0.3 ms, 4–10 V) of the great auricular nerve in vivo on sympathetic cotransmission in the rabbit isolated central ear artery was examined. 2 Chronic stimulation had no significant effect on frequency‐dependent (4–60 Hz) neurogenic con...

Full description

Saved in:
Bibliographic Details
Published in:British journal of pharmacology 1992-11, Vol.107 (3), p.833-836
Main Authors: Maynard, K.I., Loesch, A., Burnstock, G.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - analogs & derivatives
Adenosine Triphosphate - pharmacology
Animals
Arteries - drug effects
Arteries - innervation
Arteries - physiology
chronic electrical stimulation
Ear, External - blood supply
Ear, External - innervation
Electric Stimulation
Electrodes
Male
Muscle Contraction - drug effects
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - innervation
Muscle, Smooth, Vascular - metabolism
noradrenaline
Norepinephrine - pharmacology
Potassium Chloride - pharmacology
purinergic transmission
Rabbit ear artery
Rabbits
Receptors, Purinergic - drug effects
Sympathetic Nervous System - drug effects
sympathetic neurotransmission
Synaptic Transmission - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1 The effect of chronic (4–16 days) electrical stimulation (5 Hz, 0.3 ms, 4–10 V) of the great auricular nerve in vivo on sympathetic cotransmission in the rabbit isolated central ear artery was examined. 2 Chronic stimulation had no significant effect on frequency‐dependent (4–60 Hz) neurogenic contractions or contractile responses induced by exogenous noradrenaline (0.1–300 μm). 3 In contrast, contractions induced by exogenous α,β‐methylene ATP (10.0 μm) were significantly decreased in preparations from 16‐day stimulated animals in comparison with sham‐operated, 4‐day and 8‐day chronically stimulated animal groups. 4 It is concluded that chronic electrical stimulation of nerves supplying the ear artery may lead to the selective alteration of postjunctional P2x‐purinoceptor mechanisms, while the effects mediated by postjunctional α1‐adrenoceptors remain unchanged.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1992.tb14532.x