Meningococcal disease and polymorphism of FcγRIIa (CD32) in late complement component‐deficient individuals

Late complement component‐deficient (LCCD) individuals lack plasma bactericidal activity and are highly susceptible to meningococcal disease. Phagocytosis plays a significant role in immune defence against meningococci and involves FcγRIIa (CD32) on leucocytes. Two allotypic forms are currently reco...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental immunology 1998-01, Vol.111 (1), p.97-101
Main Authors: Platonov, A E, Kuijper, E J, Vershinina, I V, Shipulin, G A, Westerdaal, N, Fijen, C A P, Van De Winkel, J G J
Format: Article
Language:English
Subjects:
complement deficiency
FcγRIIa
meningococcal infection
Original
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Late complement component‐deficient (LCCD) individuals lack plasma bactericidal activity and are highly susceptible to meningococcal disease. Phagocytosis plays a significant role in immune defence against meningococci and involves FcγRIIa (CD32) on leucocytes. Two allotypic forms are currently recognized: FcγRIIa‐R131 and RIIa‐H131. Neutrophils with the IIa‐H/H131 allotype are more effective in phagocytosis than IIa‐R/R131. We studied the distributions of IIa‐R131 and IIa‐H131 allotypes among 29 Russian LCCD patients who had suffered from recurrent episodes of meningococcal disease. The distribution of IIa‐R/R131 to heterozygous IIa‐R/H131 to homozygous IIa‐H/H131 genotypes was 0.14:0.29:0.57 for LCCD patients who developed the first episode of disease before 10 years of age. The distribution was 0.21:0.64:0.14 for patients who experienced meningococcal disease above the age of 10 years (χ2 = 6, P 
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.1998.00484.x