CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers

Apart from genes in the HLA complex (IDDM1) and the variable number of tandem repeats in the 5' region of the insulin gene (INS VNTR, IDDM2), several other loci have been proposed to contribute to IDDM susceptibility. Recently, linkage and association have been shown between the cytotoxic T lym...

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Bibliographic Details
Published in:Clinical and experimental immunology 1997-10, Vol.110 (1), p.98-103
Main Authors: VAN DER AUWERA, B. J, VANDEWALLE, C. L, SCHUIT, F. C, WINNOCK, F, DE LEEUW, I. H, VAN IMSCHOOT, S, LAMBERIGTS, G, GORUS, F. K
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Medical sciences
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Summary:Apart from genes in the HLA complex (IDDM1) and the variable number of tandem repeats in the 5' region of the insulin gene (INS VNTR, IDDM2), several other loci have been proposed to contribute to IDDM susceptibility. Recently, linkage and association have been shown between the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) gene on chromosome 2q and IDDM. In a registry-based group of 525 recent-onset IDDM patients
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.1997.5121410.x