Body silhouette, menstrual function at adolescence and breast cancer risk in the E3N cohort study

We analysed the relation between adult breast cancer risk and adiposity in ages 8-25, and among 90 509 women included in the E3N cohort study, and investigated the potential modification effect of certain factors. Participants completed a questionnaire that included a set of eight silhouettes corres...

Full description

Saved in:
Bibliographic Details
Published in:Breast cancer research and treatment 2005-06, Vol.92 (11), p.2042-2048
Main Authors: TEHARD, B, KAAKS, R, CLAVEL-CHAPELON, F
Format: Article
Language:English
Subjects:
Adipose Tissue
Age
Age of Onset
Anthropometry
Biological and medical sciences
Body Composition
Body mass index
Breast cancer
Breast Neoplasms
Breast Neoplasms - epidemiology
Breast Neoplasms - etiology
Cancer
Cancer research
Child
Child development
Cohort analysis
Cohort Studies
Epidemiology
Female
Gynecology and obstetrics
Gynecology. Andrology. Obstetrics
Human health and pathology
Humans
Incidence
Life Sciences
Mammary gland diseases
Medical research
Medical sciences
Menarche
Menopause
Menstruation
Middle Aged
Nutrition
Overweight
Parity
Questionnaires
Reproductive Biology
Risk Factors
Santé publique et épidémiologie
Tumors
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We analysed the relation between adult breast cancer risk and adiposity in ages 8-25, and among 90 509 women included in the E3N cohort study, and investigated the potential modification effect of certain factors. Participants completed a questionnaire that included a set of eight silhouettes corresponding to body shape at different ages. During the follow-up (mean=11.4 years), 3491 breast cancer cases were identified. Negative trends in risk of breast cancer with increasing body silhouettes at age 8 and at menarche were observed, irrespective of menopausal status, with relative risks of 0.73 (0.53-0.99) and 0.82 (0.66-1.02) for women who reported a silhouette equal or greater than the fifth silhouette at age 8 and at menarche, respectively. We observed no clear effect modification by age at menarche, delay between age at menarche, regular cycling, regularity of cycles in adult life or body mass index at baseline.
ISSN:0007-0920
0167-6806
1532-1827
1573-7217
DOI:10.1038/sj.bjc.6602620