Reperfusion injury: Does it exist?

Abstract It is well established that reperfusion of the heart is the optimal method of salvaging previously ischemic myocardium. However, the idea of reperfusion injury, i.e. injury caused by the process of reperfusion per se , still remains a controversial issue. In this review, we present mounting...

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Bibliographic Details
Published in:	Journal of molecular and cellular cardiology 2007-01, Vol.42 (1), p.12-18
Main Authors:	Gross, Garrett J, Auchampach, John A
Format:	Article
Language:	eng
Subjects:	Adenosine Adenosine - pharmacology Animals Cardiovascular Heart Humans Ischemia/reperfusion Ischemic Preconditioning, Myocardial Ligands Mini-Review Models, Cardiovascular Myocardial Reperfusion Injury - etiology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Opioids Postconditioning Receptors, Opioid - drug effects Receptors, Opioid - physiology Receptors, Purinergic P1 - drug effects Receptors, Purinergic P1 - physiology Reperfusion injury
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Summary:	Abstract It is well established that reperfusion of the heart is the optimal method of salvaging previously ischemic myocardium. However, the idea of reperfusion injury, i.e. injury caused by the process of reperfusion per se , still remains a controversial issue. In this review, we present mounting evidence supporting the concept that reperfusion injury exists, based on work conducted with adenosine and opioid receptor ligands, and the discovery of two new concepts regarding reperfusion injury: ‘postconditioning’ (POC) and the reperfusion injury salvage kinase (RISK) signaling pathway.
ISSN:	0022-2828 1095-8584