Correlation of optical coherence tomography and fundus fluorescein angiography following photodynamic therapy for choroidal neovascular membranes

Aims: To assess the correlation between optical coherence tomography (OCT) and leakage on fundus fluorescein angiography (FFA) following photodynamic therapy (PDT) with verteporfin for choroidal neovascularisation (CNV). Methods: Retrospective comparative observational case series of patients who we...

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Bibliographic Details
Published in:British journal of ophthalmology 2006-03, Vol.90 (3), p.304-306
Main Authors: Van de Moere, A, Sandhu, S S, Talks, S J
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cardiovascular system
choroidal neovascular membrane
choroidal neovascularisation
Choroidal Neovascularization - drug therapy
Clinical Science - Scientific Report
CMO
CNV
Confidence intervals
cystoid macular oedema
Cysts
Diseases of the skin. Cosmetics
Epidemiologic Methods
Exudates and Transudates
Female
FFA
Fluorescein Angiography
fundus fluorescein angiography
GLD
greatest linear dimension
Humans
Investigative techniques, diagnostic techniques (general aspects)
Long-Term Care - methods
Macular degeneration
Male
Medical imaging
Medical sciences
Membranes
Middle Aged
Miscellaneous
OCT
Ophthalmology
optical coherence tomography
Patients
PDT
PED
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - therapeutic use
pigment epithelial detachment
Porphyrins - therapeutic use
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Recurrence
Software
SRF
subretinal fluid
Tomography, Optical Coherence
vitreomacular traction
VMT
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Summary:Aims: To assess the correlation between optical coherence tomography (OCT) and leakage on fundus fluorescein angiography (FFA) following photodynamic therapy (PDT) with verteporfin for choroidal neovascularisation (CNV). Methods: Retrospective comparative observational case series of patients who were treated with PDT for CNV from one centre. All patients had 3 monthly FFA and OCT following initial PDT to assess if further treatment was required. A pair of FFA and OCT images from the same visit at a random follow up date were taken from each patient’s series and assessed separately by different observers. The presence of pigment epithelial detachment, subretinal fluid, vitreomacular traction, intraretinal fluid, absence of foveal depression, and the retinal thickness on OCT were correlated with presence of leaks on FFA. Results: A total of 121 eyes of 121 patients were included. The presence of subretinal fluid, gross cystoid macular oedema, sponge-like retinal thickening and retinal thickness of more than 350 μm on OCT correlated well with leak on FFA (p value
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.2005.079947