Genetic polymorphisms of mannan binding lectin (MBL), serum levels of MBL, the MBL associated serine protease and H-ficolin in patients with Crohn’s disease

Age at onset of Crohn's disease, localisation and disease behaviour were classified according to the Vienna classification. 3 Plasma levels of MBL were measured by a functional time resolved immunofluorometric assay. 4 Genetic variations in exon-1 (at codons 52, 54 and 57) and polymorphisms in...

Full description

Saved in:
Bibliographic Details
Published in:Gut 2007-02, Vol.56 (2), p.311-312
Main Authors: Nielsen, R G, Vind, I, Munkholm, P, Jensenius, J C, Thiel, S, Husby, S
Format: Article
Language:English
Subjects:
Bowel disease
Classification
Crohn Disease - blood
Crohn Disease - genetics
Crohns disease
Female
Females
Genes
Genotype
Genotype & phenotype
Glycoproteins - blood
Humans
Lectins
Lectins - blood
Letter
Male
Mannose-Binding Lectin - blood
Mannose-Binding Lectin - genetics
Mannose-Binding Protein-Associated Serine Proteases - analysis
Pathogenesis
Polymorphism, Genetic - genetics
Prescription drugs
Sex Factors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Age at onset of Crohn's disease, localisation and disease behaviour were classified according to the Vienna classification. 3 Plasma levels of MBL were measured by a functional time resolved immunofluorometric assay. 4 Genetic variations in exon-1 (at codons 52, 54 and 57) and polymorphisms in the promoter region (at positions -550 (H/L) and -221 (X/Y)) were determined by a real time polymerase chain reaction technique. 5 Based on this genetic characterisation, patients were classified by structural genotype: [...]we were unable to confirm the increased frequency of MBL genotypes leading to reduced levels of MBL or MBL deficiency in Danish patients with Crohn's disease.
ISSN:0017-5749
1468-3288
DOI:10.1136/gut.2006.109504