Antiangiogenic therapy in human gastrointestinal malignancies

Vascular endothelial growth factor (VEGF) and many other angiogenic factors are endogenous ligands of receptors present on the EC surface, leading to initiation of intracellular signal transduction and gene transcription, eventually resulting in EC proliferation, active locomotion (chemotaxis), and...

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Bibliographic Details
Published in:Gut 2006-10, Vol.55 (10), p.1497-1511
Main Authors: Heidemann, J, Binion, D G, Domschke, W, Kucharzik, T
Format: Article
Language:English
Subjects:
Angiogenesis
Angiogenesis Inhibitors - therapeutic use
Animals
antiangiogenic
Biological and medical sciences
Cancer
Cancer therapies
Cells, Cultured
colorectal carcinoma
Cytokines
Extracellular matrix
Gastroenterology. Liver. Pancreas. Abdomen
gastrointestinal
Gastrointestinal Antiangiogenesis
Gastrointestinal Neoplasms - blood supply
Gastrointestinal Neoplasms - drug therapy
Gastrointestinal Neoplasms - genetics
Humans
Hypoxia
Intercellular Signaling Peptides and Proteins - metabolism
Medical sciences
Metastasis
Models, Animal
Neovascularization, Pathologic - drug therapy
Oncogenes - physiology
Physiology
Signal transduction
Smooth muscle
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
surrogate marker
Tumors
Vascular endothelial growth factor
vascularisation
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Summary:Vascular endothelial growth factor (VEGF) and many other angiogenic factors are endogenous ligands of receptors present on the EC surface, leading to initiation of intracellular signal transduction and gene transcription, eventually resulting in EC proliferation, active locomotion (chemotaxis), and degradation of the extracellular matrix (ECM) by secretion of proteases, including matrix metalloproteinases (MMP). In patients suffering from solid tumours, including lung, prostate, cervical, and colorectal carcinoma, elevated plasma D-dimer levels have been shown to be directly correlated with levels of established tumour markers such as CA 125 and CEA. [...]in colorectal cancer patients, serum D-dimer levels were found to correlate with depth of tumour invasion and lymph node involvement. 192- 194 Similar observations have been made by our group in the antiangiogenic treatment of benign intra-abdominal desmoid lesions using interferon beta and the selective oestrogen receptor modulating agent toremifene.
ISSN:0017-5749
1468-3288
DOI:10.1136/gut.2005.088229