Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study

Background: The low-density lipoprotein receptor-related protein 5 (LRP5) gene, essential for glucose and cholesterol metabolism, may have a role in the aetiology of obesity, an important risk factor for diabetes. Participants and methods: To investigate the association between LRP5 polymorphisms an...

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Bibliographic Details
Published in:Journal of medical genetics 2006-10, Vol.43 (10), p.798-803
Main Authors: Guo, Yan-fang, Xiong, Dong-hai, Shen, Hui, Zhao, Lan-juan, Xiao, Peng, Guo, Yan, Wang, Wei, Yang, Tie-lin, Recker, Robert R, Deng, Hong-wen
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
BMI
Body Composition
Body Mass Index
Bone density
Child
Confidence intervals
Diabetes
family-based association analysis
FBAT
Female
Fundamental and applied biological sciences. Psychology
General aspects. Genetic counseling
generalised linear model
Genes
Genetic Linkage
Genetics of eukaryotes. Biological and molecular evolution
GLM
haplotype version of FBAT
Haplotypes
HBAT
Humans
LDL-Receptor Related Proteins - genetics
Linkage Disequilibrium
Lipoproteins
Low Density Lipoprotein Receptor-Related Protein-5
low-density lipoprotein receptor-related protein 5 gene
LRP5 gene
MAF
Male
Medical genetics
Medical sciences
Metabolic diseases
Middle Aged
minor allele frequencies
Molecular and cellular biology
Nuclear Family
Obesity
Obesity - genetics
Original
Osteoporosis
percentage of fat mass
PFM
Phenotype
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Sex Characteristics
single-nucleotide polymorphism
SNP
Studies
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Summary:Background: The low-density lipoprotein receptor-related protein 5 (LRP5) gene, essential for glucose and cholesterol metabolism, may have a role in the aetiology of obesity, an important risk factor for diabetes. Participants and methods: To investigate the association between LRP5 polymorphisms and obesity, 27 single-nucleotide polymorphisms (SNPs), spacing about 5 kb apart on average and covering the full transcript length of the LRP5 gene, were genotyped in 1873 Caucasian people from 405 nuclear families. Obesity (defined as body mass index (BMI) >30 kg/m2) and three obesity-related phenotypes (BMI, fat mass and percentage of fat mass (PFM)) were investigated. Results: Single markers (12 tagging SNPs and 4 untaggable SNPs) and haplotypes (5 blocks) were tested for associations, using family-based designs. SNP4 (rs4988300) and SNP6 (rs634008) located in block 2 (intron 1) showed significant associations with obesity and BMI after Bonferroni correction (SNP4: p
ISSN:0022-2593
1468-6244
1468-6244
DOI:10.1136/jmg.2006.041715