Characterization of the invasion of porcine endothelial cells by Streptococcus suis serotype 2

Streptococcus suis serotype 2 is an important swine pathogen associated mainly with meningitis. In a previous study, we demonstrated the ability of S. suis serotype 2 to adhere to and invade immortalized porcine brain microvascular endothelial cells (PBMECs) forming the blood-brain barrier. The aim...

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Bibliographic Details
Published in:Canadian journal of veterinary research 2007-04, Vol.71 (2), p.81-89
Main Authors: Vanier, G, Segura, M, Gottschalk, M
Format: Article
Language:English
Subjects:
animal pathogenic bacteria
Animals
Bacterial Adhesion - physiology
Blood-Brain Barrier
Brain - blood supply
Cell Line
Culture Media - chemistry
endothelial cells
Endothelial Cells - microbiology
Endothelium, Vascular - cytology
Endothelium, Vascular - microbiology
Meningitis, Bacterial - etiology
Meningitis, Bacterial - veterinary
Serotyping
Streptococcus suis
Streptococcus suis - pathogenicity
Streptococcus suis - physiology
Swine
Swine Diseases - etiology
Swine Diseases - microbiology
Virulence
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Summary:Streptococcus suis serotype 2 is an important swine pathogen associated mainly with meningitis. In a previous study, we demonstrated the ability of S. suis serotype 2 to adhere to and invade immortalized porcine brain microvascular endothelial cells (PBMECs) forming the blood-brain barrier. The aim of the current work was to further characterize the mechanism(s) by which S. suis invades porcine endothelial cells. The ability of several S. suis strains to interact with PBMECs was not found to correlate with their geographic origin, virulence, host of origin, or suilysin production. Characterization studies demonstrated that proteinaceous adhesins/invasins, cell wall components, lipoteichoic acid, and serum components (including fibronectin) were involved in interactions between S. suis and PBMECs. In addition to PBMECs, S. suis was able to adhere to and invade 2 porcine aortic endothelial cell lines and primary PBMECs.
ISSN:0830-9000