The relation between progressive osteoarthritis of the knee and long term progression of osteoarthritis of the hand, hip, and lumbar spine

Background: The association between progression of knee osteoarthritis and progression of osteoarthritis at sites distant from the knee is unclear because of a lack of multisite longitudinal progression data. Objective: To examine the association between radiological progression of knee osteoarthrit...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the rheumatic diseases 2006-05, Vol.65 (5), p.623-628
Main Authors: Hassett, G, Hart, D J, Doyle, D V, March, L, Spector, T D
Format: Article
Language:English
Subjects:
Adult
anterior osteophyte
Arthritis
Biological and medical sciences
BMI
Body mass index
carpometacarpal joint
Clinical trials
CMC
DIP
disc space narrowing
Disease
disease modifying antirheumatic drug
Disease Progression
Diseases of the osteoarticular system
distal interphalangeal joint
DMOAD
DSN
Epidemiologic Methods
Extended Report
Female
Follow-Up Studies
Hand - diagnostic imaging
Hand - pathology
Humans
joint space narrowing
joint space width
JSN
JSW
knee
lumbar spine
Lumbar Vertebrae - diagnostic imaging
Lumbar Vertebrae - pathology
Medical sciences
Methods
Middle Aged
Miscellaneous. Osteoarticular involvement in other diseases
Osteoarthritis
Osteoarthritis - diagnostic imaging
Osteoarthritis - pathology
Osteoarthritis, Hip - diagnostic imaging
Osteoarthritis, Hip - pathology
Osteoarthritis, Knee - diagnostic imaging
Osteoarthritis, Knee - pathology
outcome
Radiography
Severity of Illness Index
Spinal Diseases - diagnostic imaging
Spinal Diseases - pathology
Studies
Womens health
X-rays
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: The association between progression of knee osteoarthritis and progression of osteoarthritis at sites distant from the knee is unclear because of a lack of multisite longitudinal progression data. Objective: To examine the association between radiological progression of knee osteoarthritis and osteoarthritis of the hands, hips, and lumbar spine in a population based cohort. Methods: 914 women had knee x rays taken 10 years apart, which were read for the presence of osteophytes and joint space narrowing (JSN). Progression status was available for hand, hip, and lumbar spine x rays over the same 8 to 10 year period. The association between progression of knee osteoarthritis and osteoarthritis at other sites was analysed using odds ratios (OR) and 95% confidence intervals (CI) in logistic regression models. Results: 89 of 133 women had progression of knee osteoarthritis based on osteophytes, and 51 of 148 based on JSN definition. Progression of JSN in the knee was predicted by progression in lumbar spine disc space narrowing (OR = 2.9 (95% CI 1.2 to 7.5)) and hip JSN (OR = 2.0 (1.0 to 4.2)). No consistent effects were seen for hand osteoarthritis. The associations remained after adjustment for age and body mass index. Conclusions: Progression of knee osteoarthritis is associated with progression of lumbar spine and hip osteoarthritis. This may have implications for trial methodology, the selection of patients for osteoarthritis research, and advice for patients on prognosis of osteoarthritis.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2005.038414