Streptococcus associated toxic shock

In the past few years, there appears to have been a change in the spectrum of disease caused by group A beta-haemolytic streptococcus (GABHS), and a toxic shock-like syndrome caused by this organism has recently been described in adults. We report four children with an acute illness characterised by...

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Bibliographic Details
Published in:	Archives of disease in childhood 1992-01, Vol.67 (1), p.126-130
Main Authors:	Torres-Martínez, C, Mehta, D, Butt, A, Levin, M
Format:	Article
Language:	eng
Subjects:	Bacterial diseases Biological and medical sciences Cardiopulmonary Resuscitation Child Combined Modality Therapy Female Human bacterial diseases Humans Infant Infant, Newborn Infectious diseases Life Sciences & Biomedicine Medical sciences Miscellaneous Pediatrics Penicillins - therapeutic use Science & Technology Shock, Septic - etiology Shock, Septic - therapy Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcal Infections - complications Streptococcus pyogenes
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Summary:	In the past few years, there appears to have been a change in the spectrum of disease caused by group A beta-haemolytic streptococcus (GABHS), and a toxic shock-like syndrome caused by this organism has recently been described in adults. We report four children with an acute illness characterised by rapid progression of shock, erythematous rash, multisystem organ involvement, electrolyte derangements, and desquamation who fulfil the previously established diagnostic criteria for toxic shock syndrome. Three of the children had extensive cutaneous and soft tissue infection and the fourth had peritonitis. All four developed bacteraemia. Treatment included aggressive cardiovascular resuscitation and antibiotic therapy. Although no patient died, they suffered multiple and severe complications requiring prolonged treatment and hospitalisation. Streptococcal toxic shock syndrome is a separate and clearly defined entity occurring in previously healthy children.
ISSN:	0003-9888 1468-2044