Anticarbamazepine antibody induced by carbamazepine in a patient with severe serum sickness

Anticarbamazepine antibody was detected in a patient who had clinical signs of serum sickness induced by carbamazepine. Skin rash, fever, oedema, and lymphadenopathy are classic signs of severe adverse reaction, but although immunological hypersensitivity is thought to be a contributory factor, the...

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Bibliographic Details
Published in:Archives of disease in childhood 1991-06, Vol.66 (6), p.722-723
Main Authors: Hosoda, N, Sunaoshi, W, Shirai, H, Bando, Y, Miura, H, Igarashi, M
Format: Article
Language:English
Subjects:
Adverse and side effects
Animals
Antibody Formation - drug effects
Biological and medical sciences
Carbamazepine
Carbamazepine - adverse effects
Carbamazepine - immunology
Case studies
Causes of
Child
Dermatitis
Drug allergy
Drug Hypersensitivity
Drug toxicity and drugs side effects treatment
Female
Humans
Inflammation
Medical sciences
Mice
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Serum sickness
Serum Sickness - chemically induced
Serum Sickness - immunology
Skin
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Summary:Anticarbamazepine antibody was detected in a patient who had clinical signs of serum sickness induced by carbamazepine. Skin rash, fever, oedema, and lymphadenopathy are classic signs of severe adverse reaction, but although immunological hypersensitivity is thought to be a contributory factor, the presence of anticarbamazepine antibody has not previously been reported to our knowledge.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.66.6.722