Depletion of trace elements and acute ocular toxicity induced by desferrioxamine in patients with thalassaemia

High doses of intravenous desferrioxamine infused over a short period of time induce a large faecal and urinary iron excretion but also produce retinal abnormalities that are characterised by decreased amplitude on electroretinography and defective dark adaptation. This regimen also results in high...

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Bibliographic Details
Published in:Archives of disease in childhood 1988-03, Vol.63 (3), p.250-255
Main Authors: De Virgiliis, S, Congia, M, Turco, M P, Frau, F, Dessi, C, Argiolu, F, Sorcinelli, R, Sitzia, A, Cao, A
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Child
Copper - deficiency
Copper - metabolism
Deferoxamine - administration & dosage
Deferoxamine - adverse effects
Deferoxamine - metabolism
Drug toxicity and drugs side effects treatment
Electroretinography
Humans
Infusions, Intravenous
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Retinal Diseases - chemically induced
Thalassemia - drug therapy
Thalassemia - metabolism
Time Factors
Zinc - deficiency
Zinc - metabolism
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Summary:High doses of intravenous desferrioxamine infused over a short period of time induce a large faecal and urinary iron excretion but also produce retinal abnormalities that are characterised by decreased amplitude on electroretinography and defective dark adaptation. This regimen also results in high faecal iron, zinc, and copper excretion, and reduced granulocyte zinc concentrations and alkaline phosphatase activity. The retinal abnormalities may be related to the zinc and copper deficiency and/or iron depletion 'per se' which interferes negatively with critical iron dependent enzymes.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.63.3.250