Comparison of four pancreatic extracts in cystic fibrosis

Four different pancreatin products, Pancrease, Creon, Pancrex V Forte, and Pancreatin Merck, were compared in a random crossover trial in children with cystic fibrosis. The results of our study showed that patients who received Creon and Pancrease had fewer gastrointestinal symptoms than patients wh...

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Bibliographic Details
Published in:Archives of disease in childhood 1987-06, Vol.62 (6), p.564-568
Main Authors: Beverley, D W, Kelleher, J, MacDonald, A, Littlewood, J M, Robinson, T, Walters, M P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Celiac Disease - chemically induced
Child
Clinical Trials as Topic
Cystic Fibrosis - drug therapy
Delayed-Action Preparations
Dietary Fats - metabolism
Feces - analysis
Humans
Intestinal Absorption
Medical sciences
Nitrogen - analysis
Pancreatin - adverse effects
Pancreatin - therapeutic use
Pharmacology. Drug treatments
Random Allocation
Respiratory system
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Summary:Four different pancreatin products, Pancrease, Creon, Pancrex V Forte, and Pancreatin Merck, were compared in a random crossover trial in children with cystic fibrosis. The results of our study showed that patients who received Creon and Pancrease had fewer gastrointestinal symptoms than patients who received Pancrex V Forte and Pancreatin Merck. Fat absorption was significantly improved with Pancrease when compared with Pancrex V forte and Pancreatin Merck. Also the fat absorption with Creon was superior to that with Pancrex V Forte. There was no significant difference in fat absorption between Pancrease and Creon. Pancrex V Forte and Pancreatin Merck, or Pancreatin Merck and Creon. Faecal nitrogen content was less with both Creon and Pancrease compared with Pancreatin Merck. Creon and Pancrease allow the patient with cystic fibrosis to take a high energy diet without any dietary restrictions.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.62.6.564