Mucosal colonisation with Lactobacillus casei mitigates barrier injury induced by exposure to trinitronbenzene sulphonic acid

Background: Trinitrobenzene sulphonic acid (TNBS) induces chronic transmural inflammatory lesions in the rat colon. Injury is facilitated by barrier disruption and invasion of commensal bacteria. However, certain bacteria have shown anti-inflammatory properties in in vitro models. Aim: To investigat...

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Published in:Gut 2005-07, Vol.54 (7), p.955-959
Main Authors: Llopis, M, Antolín, M, Guarner, F, Salas, A, Malagelada, J-R
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Bacteria
Bacterial Translocation
CFU
colitis
Colitis, Ulcerative - chemically induced
Colitis, Ulcerative - microbiology
Colitis, Ulcerative - therapy
Colon - microbiology
colony forming units
De Man Rogosa Sharp medium
Disease Models, Animal
Experiments
Gangrene
Inflammation
Inflammatory Bowel Disease
Intestinal Absorption
Intestinal Mucosa - microbiology
Laboratory animals
lactobacillus
Lactobacillus casei
Lactobacillus casei - physiology
Liver - microbiology
Lymph Nodes - microbiology
Male
mesenteric lymph nodes
MLN
MPO
MRS
mucosal barrier trinitrobenzene sulphonic acid
myeloperoxidase
Peroxidase - metabolism
probiotics
Probiotics - therapeutic use
Rats
Rats, Sprague-Dawley
Rodents
Small intestine
Spleen - microbiology
Studies
Surgery
TNBS
trinitrobenzene sulphonic acid
Trinitrobenzenesulfonic Acid
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creator Llopis, M
Antolín, M
Guarner, F
Salas, A
Malagelada, J-R
description Background: Trinitrobenzene sulphonic acid (TNBS) induces chronic transmural inflammatory lesions in the rat colon. Injury is facilitated by barrier disruption and invasion of commensal bacteria. However, certain bacteria have shown anti-inflammatory properties in in vitro models. Aim: To investigate in vivo the anti-inflammatory effect of Lactobacillus casei DN-114 001. Methods: Rats with a colonic segment excluded from faecal transit were surgically prepared. After washing the lumen with antibiotics, the excluded segment was recolonised (control group: standard flora of rat origin; test group: standard flora and L casei). Microbial colonisation was confirmed by culture of segment washing, and colitis was then induced by instillation of TNBS. One day after, intestinal lesions were blindly graded by macro- and microscopic scores, and myeloperoxidase activity measured in tissue homogenates. Translocation of bacteria to mesenteric lymph nodes, spleen and liver was investigated. Results: Test rats showed a smaller area of mucosal injury than control rats (p
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Injury is facilitated by barrier disruption and invasion of commensal bacteria. However, certain bacteria have shown anti-inflammatory properties in in vitro models. Aim: To investigate in vivo the anti-inflammatory effect of Lactobacillus casei DN-114 001. Methods: Rats with a colonic segment excluded from faecal transit were surgically prepared. After washing the lumen with antibiotics, the excluded segment was recolonised (control group: standard flora of rat origin; test group: standard flora and L casei). Microbial colonisation was confirmed by culture of segment washing, and colitis was then induced by instillation of TNBS. One day after, intestinal lesions were blindly graded by macro- and microscopic scores, and myeloperoxidase activity measured in tissue homogenates. Translocation of bacteria to mesenteric lymph nodes, spleen and liver was investigated. Results: Test rats showed a smaller area of mucosal injury than control rats (p&lt;0.05). Maximum depth lesion scores were similar in both groups but myeloperoxidase activity was lower in test than in control rats (p&lt;0.05). Remarkably, bacterial translocation was quantitatively lower (p&lt;0.01) and less frequent (p&lt;0.05) in test than in control rats. Conclusion: In rats colonised with L casei, mucosal injury, inflammatory response, and barrier disruption after TNBS challenge were attenuated. Bacterial communities colonising the mucosa can modify inflammatory responses to luminal challenges.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>EISSN: 1458-3288</identifier><identifier>DOI: 10.1136/gut.2004.056101</identifier><identifier>PMID: 15951541</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Animals ; Antibiotics ; Bacteria ; Bacterial Translocation ; CFU ; colitis ; Colitis, Ulcerative - chemically induced ; Colitis, Ulcerative - microbiology ; Colitis, Ulcerative - therapy ; Colon - microbiology ; colony forming units ; De Man Rogosa Sharp medium ; Disease Models, Animal ; Experiments ; Gangrene ; Inflammation ; Inflammatory Bowel Disease ; Intestinal Absorption ; Intestinal Mucosa - microbiology ; Laboratory animals ; lactobacillus ; Lactobacillus casei ; Lactobacillus casei - physiology ; Liver - microbiology ; Lymph Nodes - microbiology ; Male ; mesenteric lymph nodes ; MLN ; MPO ; MRS ; mucosal barrier trinitrobenzene sulphonic acid ; myeloperoxidase ; Peroxidase - metabolism ; probiotics ; Probiotics - therapeutic use ; Rats ; Rats, Sprague-Dawley ; Rodents ; Small intestine ; Spleen - microbiology ; Studies ; Surgery ; TNBS ; trinitrobenzene sulphonic acid ; Trinitrobenzenesulfonic Acid</subject><ispartof>Gut, 2005-07, Vol.54 (7), p.955-959</ispartof><rights>Copyright 2005 by Gut</rights><rights>Copyright: 2005 Copyright 2005 by Gut</rights><rights>Copyright © Copyright 2005 by Gut 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b523t-e11233d57a400932da9a835b616d4a29a3571f35744148a5fb323740e44a55443</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774610/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774610/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15951541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Llopis, M</creatorcontrib><creatorcontrib>Antolín, M</creatorcontrib><creatorcontrib>Guarner, F</creatorcontrib><creatorcontrib>Salas, A</creatorcontrib><creatorcontrib>Malagelada, J-R</creatorcontrib><title>Mucosal colonisation with Lactobacillus casei mitigates barrier injury induced by exposure to trinitronbenzene sulphonic acid</title><title>Gut</title><addtitle>Gut</addtitle><description>Background: Trinitrobenzene sulphonic acid (TNBS) induces chronic transmural inflammatory lesions in the rat colon. Injury is facilitated by barrier disruption and invasion of commensal bacteria. However, certain bacteria have shown anti-inflammatory properties in in vitro models. Aim: To investigate in vivo the anti-inflammatory effect of Lactobacillus casei DN-114 001. Methods: Rats with a colonic segment excluded from faecal transit were surgically prepared. After washing the lumen with antibiotics, the excluded segment was recolonised (control group: standard flora of rat origin; test group: standard flora and L casei). Microbial colonisation was confirmed by culture of segment washing, and colitis was then induced by instillation of TNBS. One day after, intestinal lesions were blindly graded by macro- and microscopic scores, and myeloperoxidase activity measured in tissue homogenates. Translocation of bacteria to mesenteric lymph nodes, spleen and liver was investigated. Results: Test rats showed a smaller area of mucosal injury than control rats (p&lt;0.05). Maximum depth lesion scores were similar in both groups but myeloperoxidase activity was lower in test than in control rats (p&lt;0.05). Remarkably, bacterial translocation was quantitatively lower (p&lt;0.01) and less frequent (p&lt;0.05) in test than in control rats. Conclusion: In rats colonised with L casei, mucosal injury, inflammatory response, and barrier disruption after TNBS challenge were attenuated. Bacterial communities colonising the mucosa can modify inflammatory responses to luminal challenges.</description><subject>Animals</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bacterial Translocation</subject><subject>CFU</subject><subject>colitis</subject><subject>Colitis, Ulcerative - chemically induced</subject><subject>Colitis, Ulcerative - microbiology</subject><subject>Colitis, Ulcerative - therapy</subject><subject>Colon - microbiology</subject><subject>colony forming units</subject><subject>De Man Rogosa Sharp medium</subject><subject>Disease Models, Animal</subject><subject>Experiments</subject><subject>Gangrene</subject><subject>Inflammation</subject><subject>Inflammatory Bowel Disease</subject><subject>Intestinal Absorption</subject><subject>Intestinal Mucosa - microbiology</subject><subject>Laboratory animals</subject><subject>lactobacillus</subject><subject>Lactobacillus casei</subject><subject>Lactobacillus casei - physiology</subject><subject>Liver - microbiology</subject><subject>Lymph Nodes - microbiology</subject><subject>Male</subject><subject>mesenteric lymph nodes</subject><subject>MLN</subject><subject>MPO</subject><subject>MRS</subject><subject>mucosal barrier trinitrobenzene sulphonic acid</subject><subject>myeloperoxidase</subject><subject>Peroxidase - metabolism</subject><subject>probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Small intestine</subject><subject>Spleen - microbiology</subject><subject>Studies</subject><subject>Surgery</subject><subject>TNBS</subject><subject>trinitrobenzene sulphonic acid</subject><subject>Trinitrobenzenesulfonic Acid</subject><issn>0017-5749</issn><issn>1468-3288</issn><issn>1458-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkctvEzEQhy0EomnhzA1ZQuJQaVPP2l7vXpCqiAJSykMCDr1Y3l0ncdi1gx_QIPG_42ij8rhw8Rzm8zce_xB6AmQOQKuLdYrzkhA2J7wCAvfQDFhVF7Ss6_toRgiIggvWnKDTELaEkLpu4CE6Ad5w4Axm6Od16lxQA-7c4KwJKhpn8XcTN3ipuuha1ZlhSAF3KmiDRxPNWkUdcKu8N9pjY7fJ73PpU6d73O6xvt25kLzG0eHojTXRO9tq-0NbjUMadps8qMNZ3D9CD1ZqCPrxsZ6hT1cvPy5eF8t3r94sLpdFy0saCw1QUtpzoRghDS171aia8raCqmeqbBTlAlb5YAxYrfiqpSUVjGjGFOeM0TP0YvLuUjvqvtM2ejXInTej8nvplJF_d6zZyLX7JkEIlj82C54fBd59TTpEOZrQ6WFQVrsUJDRlXTUlZPDZP-DWJW_zcgdXQymIRmTqYqI670LwenX3FCDyEKzMwcpDsHIKNt94-ucGv_ljkhkoJsCEqG_v-sp_kZWggsu3nxfy_fXiw_KGX8mbzJ9PfDtu_zv9F95Fvcw</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Llopis, M</creator><creator>Antolín, M</creator><creator>Guarner, F</creator><creator>Salas, A</creator><creator>Malagelada, J-R</creator><general>BMJ Publishing Group Ltd and British Society of Gastroenterology</general><general>BMJ Publishing Group LTD</general><general>Copyright 2005 by Gut</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QL</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>200507</creationdate><title>Mucosal colonisation with Lactobacillus casei mitigates barrier injury induced by exposure to trinitronbenzene sulphonic acid</title><author>Llopis, M ; Antolín, M ; Guarner, F ; Salas, A ; Malagelada, J-R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b523t-e11233d57a400932da9a835b616d4a29a3571f35744148a5fb323740e44a55443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Bacterial Translocation</topic><topic>CFU</topic><topic>colitis</topic><topic>Colitis, Ulcerative - chemically induced</topic><topic>Colitis, Ulcerative - microbiology</topic><topic>Colitis, Ulcerative - therapy</topic><topic>Colon - microbiology</topic><topic>colony forming units</topic><topic>De Man Rogosa Sharp medium</topic><topic>Disease Models, Animal</topic><topic>Experiments</topic><topic>Gangrene</topic><topic>Inflammation</topic><topic>Inflammatory Bowel Disease</topic><topic>Intestinal Absorption</topic><topic>Intestinal Mucosa - microbiology</topic><topic>Laboratory animals</topic><topic>lactobacillus</topic><topic>Lactobacillus casei</topic><topic>Lactobacillus casei - physiology</topic><topic>Liver - microbiology</topic><topic>Lymph Nodes - microbiology</topic><topic>Male</topic><topic>mesenteric lymph nodes</topic><topic>MLN</topic><topic>MPO</topic><topic>MRS</topic><topic>mucosal barrier trinitrobenzene sulphonic acid</topic><topic>myeloperoxidase</topic><topic>Peroxidase - metabolism</topic><topic>probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Small intestine</topic><topic>Spleen - microbiology</topic><topic>Studies</topic><topic>Surgery</topic><topic>TNBS</topic><topic>trinitrobenzene sulphonic acid</topic><topic>Trinitrobenzenesulfonic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Llopis, M</creatorcontrib><creatorcontrib>Antolín, M</creatorcontrib><creatorcontrib>Guarner, F</creatorcontrib><creatorcontrib>Salas, A</creatorcontrib><creatorcontrib>Malagelada, J-R</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>PHMC-Proquest健康医学期刊库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Llopis, M</au><au>Antolín, M</au><au>Guarner, F</au><au>Salas, A</au><au>Malagelada, J-R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucosal colonisation with Lactobacillus casei mitigates barrier injury induced by exposure to trinitronbenzene sulphonic acid</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>2005-07</date><risdate>2005</risdate><volume>54</volume><issue>7</issue><spage>955</spage><epage>959</epage><pages>955-959</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><eissn>1458-3288</eissn><coden>GUTTAK</coden><notes>istex:34EFEA2FC8EF84AB39D9BC117E405CAB2FB78929</notes><notes>ark:/67375/NVC-PMCQLZ5F-Z</notes><notes>href:gutjnl-54-955.pdf</notes><notes>local:0540955</notes><notes>PMID:15951541</notes><notes>Correspondence to:
 Dr F Guarner
 Digestive System Research Unit, Hospital General Vall d’Hebron, Barcelona 08035, Spain; fguarnera@medynet.com</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Correspondence to: …Dr F Guarner …Digestive System Research Unit, Hospital General Vall d’Hebron, Barcelona 08035, Spain; fguarnera@medynet.com</notes><notes>Conflict of interest: None declared.</notes><abstract>Background: Trinitrobenzene sulphonic acid (TNBS) induces chronic transmural inflammatory lesions in the rat colon. Injury is facilitated by barrier disruption and invasion of commensal bacteria. However, certain bacteria have shown anti-inflammatory properties in in vitro models. Aim: To investigate in vivo the anti-inflammatory effect of Lactobacillus casei DN-114 001. Methods: Rats with a colonic segment excluded from faecal transit were surgically prepared. After washing the lumen with antibiotics, the excluded segment was recolonised (control group: standard flora of rat origin; test group: standard flora and L casei). Microbial colonisation was confirmed by culture of segment washing, and colitis was then induced by instillation of TNBS. One day after, intestinal lesions were blindly graded by macro- and microscopic scores, and myeloperoxidase activity measured in tissue homogenates. Translocation of bacteria to mesenteric lymph nodes, spleen and liver was investigated. Results: Test rats showed a smaller area of mucosal injury than control rats (p&lt;0.05). Maximum depth lesion scores were similar in both groups but myeloperoxidase activity was lower in test than in control rats (p&lt;0.05). Remarkably, bacterial translocation was quantitatively lower (p&lt;0.01) and less frequent (p&lt;0.05) in test than in control rats. Conclusion: In rats colonised with L casei, mucosal injury, inflammatory response, and barrier disruption after TNBS challenge were attenuated. Bacterial communities colonising the mucosa can modify inflammatory responses to luminal challenges.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>15951541</pmid><doi>10.1136/gut.2004.056101</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects Animals
Antibiotics
Bacteria
Bacterial Translocation
CFU
colitis
Colitis, Ulcerative - chemically induced
Colitis, Ulcerative - microbiology
Colitis, Ulcerative - therapy
Colon - microbiology
colony forming units
De Man Rogosa Sharp medium
Disease Models, Animal
Experiments
Gangrene
Inflammation
Inflammatory Bowel Disease
Intestinal Absorption
Intestinal Mucosa - microbiology
Laboratory animals
lactobacillus
Lactobacillus casei
Lactobacillus casei - physiology
Liver - microbiology
Lymph Nodes - microbiology
Male
mesenteric lymph nodes
MLN
MPO
MRS
mucosal barrier trinitrobenzene sulphonic acid
myeloperoxidase
Peroxidase - metabolism
probiotics
Probiotics - therapeutic use
Rats
Rats, Sprague-Dawley
Rodents
Small intestine
Spleen - microbiology
Studies
Surgery
TNBS
trinitrobenzene sulphonic acid
Trinitrobenzenesulfonic Acid
title Mucosal colonisation with Lactobacillus casei mitigates barrier injury induced by exposure to trinitronbenzene sulphonic acid
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