Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication

Aim: To determine the incidence of ocular toxicity of preservatives with glaucoma medications. Methods: A prospective epidemiological survey was carried out in 1999 by 249 ophthalmologists on 4107 patients. Ocular symptoms, conjunctiva, cornea, and eyelids were assessed. A χ2 test was used for diffe...

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Bibliographic Details
Published in:British journal of ophthalmology 2002-04, Vol.86 (4), p.418-423
Main Authors: Pisella, P J, Pouliquen, P, Baudouin, C
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Care and treatment
Child
Child, Preschool
Clinical Science
Complications and side effects
Cross-Sectional Studies
Cytotoxicity
Drug dosages
Drug therapy
Drug toxicity and drugs side effects treatment
Eye diseases
Eye Diseases - chemically induced
Female
France - epidemiology
Glaucoma
Glaucoma - drug therapy
Humans
Inflammation
Male
Medical personnel
Medical sciences
Medical treatment
Middle Aged
ocular surface damage
Ophthalmic drugs
Ophthalmic Solutions - adverse effects
Ophthalmology
Patients
Pharmacology. Drug treatments
preservatives
Preservatives, Pharmaceutical - adverse effects
Prevalence
Prospective Studies
Retinopathies
Studies
Toxicity: eye
Citations: Items that cite this one
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Summary:Aim: To determine the incidence of ocular toxicity of preservatives with glaucoma medications. Methods: A prospective epidemiological survey was carried out in 1999 by 249 ophthalmologists on 4107 patients. Ocular symptoms, conjunctiva, cornea, and eyelids were assessed. A χ2 test was used for differences between preserved eye drops (P) and preservative free eye drops (PF). Results: 84% patients used P, 13% received PF, and 3% a combination of P and PF eye drops. All symptoms were more prevalent with P than with PF drops (p2 times) of ocular signs was seen with P eye drops. The prevalence of signs and symptoms was dose dependent, increasing with the number of P drops. A reduction in the symptoms and signs was observed when patients changed from P to PF eye drops (p
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.86.4.418