The relation between bone marrow angiogenesis and the proliferation index Ki-67 in multiple myeloma

Aim: Angiogenesis correlates with disease progression in various haematological malignancies. This study investigated the association between microvascular density (MVD) and the Ki-67 proliferation index (Ki-67 PI), bone marrow infiltration, and C reactive protein (CRP) in patients with multiple mye...

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Bibliographic Details
Published in:Journal of clinical pathology 2004-08, Vol.57 (8), p.856-860
Main Authors: Alexandrakis, M G, Passam, F H, Dambaki, C, Pappa, C A, Stathopoulos, E N
Format: Article
Language:English
Subjects:
Acute Disease
ADP-ribosyl Cyclase - analysis
ADP-ribosyl Cyclase 1
Adult
Aged
Aged, 80 and over
alkaline–antialkaline phosphatase
Analysis of Variance
Angiogenesis
Antigens, CD - analysis
APAAP
Biological and medical sciences
Biomarkers - analysis
Biopsy
Bone marrow
Bone Marrow Cells - pathology
C-Reactive Protein - analysis
Cell cycle
Cell Division
Chemotherapy
CRP
C reactive protein
Female
Hematologic and hematopoietic diseases
Hematology
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunohistochemistry - methods
Immunopathology
Investigative techniques, diagnostic techniques (general aspects)
Ki-67
Ki-67 Antigen - analysis
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma
Male
Medical prognosis
Medical sciences
Membrane Glycoproteins
microvascular density
Middle Aged
Multiple myeloma
Multiple Myeloma - drug therapy
Multiple Myeloma - pathology
MVD
Neovascularization, Pathologic - pathology
Original
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Phosphatase
Plasma
Prognosis
proliferation index
Statistics, Nonparametric
Studies
TBS
Tris buffered saline
Tumors
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Summary:Aim: Angiogenesis correlates with disease progression in various haematological malignancies. This study investigated the association between microvascular density (MVD) and the Ki-67 proliferation index (Ki-67 PI), bone marrow infiltration, and C reactive protein (CRP) in patients with multiple myeloma. Methods: Bone marrow MVD was examined in 44 biopsies at diagnosis and 15 in plateau phase by immunostaining the endothelial cells with a monoclonal antibody to CD34. The Ki-67 PI was evaluated by a double immunostaining technique using the monoclonal antibodies MIB-1 and CD38. Results: MVD, Ki-67 PI, bone marrow infiltration, and CRP were significantly higher in pretreatment patients than in controls and decreased in patients achieving plateau phase. MVD significantly correlated with Ki-67 PI and infiltration, and Ki-67 correlated with infiltration. Conclusion: In multiple myeloma, apart from being a marker of proliferative activity, Ki-67 is also associated with bone marrow angiogenesis and tumour burden.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.2003.013110