B cell signalling as therapeutic target

Again, germinal centres form but are not able to support production of specific antibodies. 27 We have found that the differentiation and proliferation of B cells in the FDC pole of the germinal centre is defective, while proliferation in the FDC-free zone is normal (Y Wang and R H Carter, manuscrip...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the rheumatic diseases 2004-11, Vol.63 (suppl 2), p.ii65-ii66
Main Author: Carter, R H
Format: Article
Language:English
Subjects:
(NF)AT
(nuclear factor) of activated T cells
Autoimmune Diseases - drug therapy
Autoimmune Diseases - immunology
autoimmunity
B cell activation
B lymphocyte stimulator
B-Lymphocytes - drug effects
B-Lymphocytes - immunology
Biological and medical sciences
BLyS
Bruton’s tyrosine kinase
Btk
Diseases of the osteoarticular system
FDC
follicular dendritic cell
Humans
Immunologic Factors - pharmacology
Lymphocyte Activation - drug effects
Lymphocyte receptors
MAPK
Medical sciences
mitogen activated protein kinase
PALS
periarteriolar lymphoid sheath
phospholipase C
PLC
Rodents
Signal Transduction - drug effects
signalling pathways
Spleen
T cell receptors
therapeutic targets
TLR
toll-like receptor
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Again, germinal centres form but are not able to support production of specific antibodies. 27 We have found that the differentiation and proliferation of B cells in the FDC pole of the germinal centre is defective, while proliferation in the FDC-free zone is normal (Y Wang and R H Carter, manuscript in preparation). [...]different specific signals could be targeted that block specific aspects of the germinal centre response. Except in germinal centres, the switched B cells are relatively rare in the white pulp of the spleen. [...]the switched, postgerminal centre memory B cells appear to leave the spleen and likely reside in the bone marrow.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2004.028282