Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin‐induced diabetes in rats

The formation of advanced glycation endproducts (AGEs) on collagen within the arterial wall may be responsible for the development of diabetic vascular injury. This study was to examine the role of aminoguanidine (AG), an inhibitor of AGEs formation, in the prevention of arterial stiffening and card...

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Bibliographic Details
Published in:British journal of pharmacology 2006-04, Vol.147 (8), p.944-950
Main Authors: Chang, Kuo‐Chu, Hsu, Kwan‐Lih, Tseng, Chuen‐Den, Lin, Yue‐Der, Cho, Yi‐Li, Tseng, Yung‐Zu
Format: Article
Language:English
Subjects:
Advanced glycation endproducts
aminoguanidine
Animals
Aorta - drug effects
aortic input impedance
Biological and medical sciences
Blood Pressure - drug effects
Cardiomegaly - prevention & control
Diabetes Mellitus, Experimental - drug therapy
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Enzyme Inhibitors - therapeutic use
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Guanidines - therapeutic use
Male
Medical sciences
Pharmacology. Drug treatments
pulse wave reflection
Rats
Rats, Wistar
streptozotocin‐diabetic rats
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Summary:The formation of advanced glycation endproducts (AGEs) on collagen within the arterial wall may be responsible for the development of diabetic vascular injury. This study was to examine the role of aminoguanidine (AG), an inhibitor of AGEs formation, in the prevention of arterial stiffening and cardiac hypertrophy in streptozotocin (STZ) induced diabetes in rats. Diabetes was induced in animals by a single tail vein injection with 65 mg kg−1 STZ. After confirmation of the development of hyperglycemia (2 days later), rats were treated for 8 weeks with AG (daily peritoneal injections of 50 mg kg−1) and compared with the age‐matched untreated diabetic controls. After exposure to AG, the STZ‐diabetic rats showed no alterations in cardiac output, aortic pressure profiles, total peripheral resistance, and aortic characteristic impedance. By contrast, treatment of this experimental diabetes with AG resulted in a significant increase in wave transit time (τ), from 20.4±0.6 to 24.7±0.5 ms (P
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0706684