Correlation of oesophageal acid exposure with Barrett's oesophagus length

BACKGROUND Gastro-oesophageal reflux disease (GORD) plays a major role in the development of Barrett's oesophagus. However, it has yet to be elucidated what factors determine the length of Barrett's mucosa in each individual patient. AIMS To determine if there is a correlation between oeso...

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Bibliographic Details
Published in:Gut 2001-03, Vol.48 (3), p.310-313
Main Authors: Fass, R, Hell, R W, Garewal, H S, Martinez, P, Pulliam, G, Wendel, C, Sampliner, R E
Format: Article
Language:English
Subjects:
Acids
Adult
Aged
Aged, 80 and over
Barrett Esophagus - etiology
Barrett Esophagus - pathology
Barrett's esophagus
Barrett's oesophagus
Biological and medical sciences
Biopsy
Causes of
Complications and side effects
Endoscopy
Esophagus
Gastric Mucosa - chemistry
Gastroenterology. Liver. Pancreas. Abdomen
Gastroesophageal reflux
Gastroesophageal Reflux - complications
Gastroesophageal Reflux - pathology
Hiatal hernias
Humans
Hydrogen-Ion Concentration
intestinal metaplasia
Male
Medical sciences
Middle Aged
oesophageal acid exposure
oesophageal pH monitoring
Other diseases. Semiology
Prospective Studies
Risk Factors
Time Factors
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Summary:BACKGROUND Gastro-oesophageal reflux disease (GORD) plays a major role in the development of Barrett's oesophagus. However, it has yet to be elucidated what factors determine the length of Barrett's mucosa in each individual patient. AIMS To determine if there is a correlation between oesophageal acid exposure and the length of Barrett's mucosa. We also compared the extent of oesophageal acid exposure between patients with short segment (SSBE) and long segment (LSBE) Barrett's oesophagus. METHODS Twenty seven patients with Barrett's oesophagus were recruited prospectively into the study from the outpatient gastroenterology clinic at the Southern Arizona VA Health Care System. Diagnosis of Barrett's oesophagus and its anatomical characteristics were determined during upper endoscopy. Ambulatory 24 hour oesophageal pH monitoring assessed the extent of oesophageal acid exposure. RESULTS There was a significant correlation between per cent total time pH less than 4 and length of Barrett's mucosa (r=0.6234, p=0.0005). In addition, there was a significant correlation between per cent upright and supine time pH less than 4 and length of Barrett's mucosa (r=0.5847, p=0.0014 andr=0.6265 p=0.0006, respectively). Patients with SSBE had significantly less oesophageal acid exposure than patients with LSBE, in terms of both per cent total time and per cent supine time pH less than 4 (p
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.48.3.310