Experience with infliximab (anti-TNFα monoclonal antibody) as monotherapy for giant cell arteritis

[...]we decided to try it in two of our patients with GCA, without concomitant administration of corticosteroids, hoping that if only a few infusions of anti-TNFα cured the disease then the side effects of chronic steroid treatment might be avoided. [...]an association between GCA with different TN...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2003-11, Vol.62 (11), p.1116-1116
Main Authors: Andonopoulos, A P, Meimaris, N, Daoussis, D, Bounas, A, Giannopoulos, G
Format: Article
Language:English
Subjects:
Adrenocortical hormones
Aged
Aged, 80 and over
Analysis
Antibodies, Monoclonal - therapeutic use
Antirheumatic Agents - therapeutic use
Care and treatment
Case studies
Complications and side effects
Corticosteroids
Drug therapy
Genetic aspects
Giant cell arteritis
Giant Cell Arteritis - drug therapy
Health aspects
Humans
Infliximab
Letter
Male
Medical research
Medicine, Experimental
Patients
Physiological aspects
Prevention
Rheumatic diseases
Testing
Time Factors
Tumor necrosis factor-TNF
tumour necrosis factor α
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Description
Summary:[...]we decided to try it in two of our patients with GCA, without concomitant administration of corticosteroids, hoping that if only a few infusions of anti-TNFα cured the disease then the side effects of chronic steroid treatment might be avoided. [...]an association between GCA with different TNFα microsatellite polymorphisms has been reported. 7 However, the initial dramatic response of our patients was not followed by a sustained improvement.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.62.11.1116