The F158V polymorphism in FcγRIIIA shows disparate associations with rheumatoid arthritis in two genetically distinct populations

Objectives: To investigate the association of the FcγRIIIA gene with rheumatoid arthritis (RA) in two genetically distinct groups: a white group from the United Kingdom and a northern Indian group. Methods: The distributions of the two alleles of the FcγRIIIA F158V polymorphism were determined in 39...

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Bibliographic Details
Published in:	Annals of the rheumatic diseases 2002-11, Vol.61 (11), p.1021-1023
Main Authors:	Milicic, A, Misra, R, Agrawal, S, Aggarwal, A, Brown, M A, Wordsworth, B P
Format:	Article
Language:	eng
Subjects:	ADCC antibody dependent cytotoxicity Biological and medical sciences Concise Report confidence interval Diseases of the osteoarticular system Fcγ receptor IIIA FcγRIIIa Genetic aspects genetics ICA IL2 immune complex mediated arthritis Inflammatory joint diseases interleukin-2 Medical genetics Medical sciences natural killer odds ratio PCR-RFLP phenylalanine polymerase chain reaction restriction fragment length polymorphism polymorphism relative risk Rheumatoid arthritis rheumatoid factor SLE systemic lupus erythematosus valine
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Summary:	Objectives: To investigate the association of the FcγRIIIA gene with rheumatoid arthritis (RA) in two genetically distinct groups: a white group from the United Kingdom and a northern Indian group. Methods: The distributions of the two alleles of the FcγRIIIA F158V polymorphism were determined in 398 white patients from the United Kingdom and 63 Indian patients with RA and compared with those from 289 United Kingdom and 93 Indian healthy controls, respectively. Results: Among the Indian patients, the frequency of the rare 158V allele and the proportion of 158VV homozygotes were reduced (relative risk (RR)=0.3, 95% confidence interval (95% CI) 0.1 to 1.1, p
ISSN:	0003-4967 1468-2060