Intestinal permeability in Behçet's syndrome

OBJECTIVE To measure the intestinal permeability in patients with Behçet's syndrome (BS) and to compare the results with those obtained from healthy and diseased controls. METHOD The study group comprised 34 patients with BS without known gastrointestinal disease. Ten patients with ankylosing s...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2001-01, Vol.60 (1), p.65-66
Main Authors: Fresko, I, Hamuryudan, V, Demir, M, Hızlı, N, Sayman, H, Melikoğlu, M, Tunç, R, Yurdakul, S, Yazıcı, H
Format: Article
Language:English
Subjects:
51Cr-EDTA
Adult
Behcet Syndrome - physiopathology
Behçet's disease
Biological and medical sciences
Chromium Radioisotopes
Concise Report
Edetic Acid
Female
Hospitals
Humans
Inflammation
Inflammatory bowel disease
Inflammatory Bowel Diseases - physiopathology
Intestinal Absorption
Lupus
Lupus Erythematosus, Systemic - physiopathology
Male
Medical sciences
Molecular weight
Permeability
Radioactivity
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Spondylitis, Ankylosing - physiopathology
Urine
Variance analysis
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Summary:OBJECTIVE To measure the intestinal permeability in patients with Behçet's syndrome (BS) and to compare the results with those obtained from healthy and diseased controls. METHOD The study group comprised 34 patients with BS without known gastrointestinal disease. Ten patients with ankylosing spondylitis (AS), 6 with inflammatory bowel diseases (IBD), 17 with systemic lupus erythematosus (SLE), and 15 healthy subjects (HC) constituted the controls. All patients received 100 μCi (3.7 MBq) of chromium-51 EDTA (51Cr-EDTA) as a radioactive tracer after a 72 hour abstinence from all drugs. The percentage of the isotope excreted in a 24 hour urinary specimen was the measure of permeability. RESULTS The percentage (SD) rate of excretion of 51Cr-EDTA was 4.6 (2.6) in BS, 6 (2.4) in AS, 5.2 (1.9) in IBD, 5.56 (1.78) in SLE, and 2.3 (1) in healthy controls. (Analysis of variance: f=6.4, p=0.0002. BSv HC, AS vHC, SLE v HC significant.) CONCLUSION The intestinal permeability in BS was significantly more than that seen among the healthy controls. Similar results in all the diseased controls cast doubt on its specificity.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.60.1.65