Intra-arterial thrombolysis in 24 consecutive patients with internal carotid artery T occlusions

Objectives: To determine the safety, efficacy, and predictors of favourable outcome of intra-arterial thrombolysis in acute stroke attributable to internal carotid “T”occlusion Methods: The authors analysed 24 consecutive patients with T occlusions of the internal carotid artery treated by local int...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2003-06, Vol.74 (6), p.739-742
Main Authors: Arnold, M, Nedeltchev, K, Mattle, H P, Loher, T J, Stepper, F, Schroth, G, Brekenfeld, C, Sturzenegger, M, Remonda, L
Format: Article
Language:English
Subjects:
ACA
Adult
Aged
anterior cerebral artery
Arterial occlusions
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Care and treatment
Carotid arteries
carotid artery T occlusions
Carotid Artery Thrombosis - diagnostic imaging
Carotid Artery Thrombosis - drug therapy
Cerebral Angiography - methods
Clinical outcomes
computed tomography
CTO
Evaluation
Female
Humans
ICA
Infusions, Intra-Arterial
internal carotid artery
intra-arterial thrombolysis
Ischemia
Male
MCA
Medical imaging
Medical sciences
Middle Aged
middle cerebral artery
modified Rankin scale
mRS
National Institutes of Health Stroke Scale
NIHSS
Patient outcomes
Pharmacology. Drug treatments
Plasminogen Activators - administration & dosage
Plasminogen Activators - therapeutic use
Stroke
Stroke (Disease)
Surveys and Questionnaires
Thrombolytic Therapy
Treatment Outcome
Urokinase-Type Plasminogen Activator - administration & dosage
Urokinase-Type Plasminogen Activator - therapeutic use
Veins & arteries
Citations: Items that cite this one
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Summary:Objectives: To determine the safety, efficacy, and predictors of favourable outcome of intra-arterial thrombolysis in acute stroke attributable to internal carotid “T”occlusion Methods: The authors analysed 24 consecutive patients with T occlusions of the internal carotid artery treated by local intra-arterial thrombolysis using urokinase. Results: The median baseline National Institutes of Health Stroke Scale was 19. The average time from symptom onset to treatment was 237 minutes. Four patients (16.6%) had a favourable (modified Rankin Scale score (mRS⩽2)) and 10 patients (41.7%) a poor outcome (mRS 3 or 4) after three months. Ten patients (41.7%) died. One symptomatic intracerebral haemorrhage (4.2%) occurred. Partial recanalisation of the intracranial internal carotid artery was achieved in 15 (63%), of the middle cerebral artery in four (17%), and of the anterior cerebral artery in eight patients (33%). Complete recanalisation never occurred. Sufficient leptomeningeal collaterals as seen on arteriography (p=0.02) and age
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.74.6.739