Neuromuscular and sensory disturbances in patients with well treated coeliac disease

Objectives: A body of evidence shows that coeliac disease is associated with protean manifestations outside the intestine, and neurological disorders are well recognised. However, it remains obscure whether there are signs of clinical or subclinical nervous system involvement even in patients adopti...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2003-04, Vol.74 (4), p.490-494
Main Authors: Luostarinen, L, Himanen, S-L, Luostarinen, M, Collin, P, Pirttilä, T
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Atrophy
Biological and medical sciences
Celiac disease
Celiac Disease - complications
Celiac Disease - physiopathology
Celiac Disease - therapy
coeliac disease
Cross-Sectional Studies
Diabetes
Diet
Electromyography
electroneuromyography
EMG
ENMG
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gastroesophageal Reflux - complications
Gastroesophageal Reflux - physiopathology
Gastroesophageal Reflux - therapy
Gluten
gluten free diet
Humans
Male
Medical sciences
Middle Aged
motor unit potential
MUP
myopathy
Neuromuscular Diseases - etiology
Neuromuscular Diseases - physiopathology
neuropathy
Nutrition research
Other diseases. Semiology
Patients
Peripheral neuropathy
Risk Factors
Sensation Disorders - etiology
Sensation Disorders - physiopathology
Sensory Thresholds - physiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Vitamin deficiency
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives: A body of evidence shows that coeliac disease is associated with protean manifestations outside the intestine, and neurological disorders are well recognised. However, it remains obscure whether there are signs of clinical or subclinical nervous system involvement even in patients adopting an adequate gluten free diet. The aim of this study was to assess in a controlled study whether patients with treated coeliac disease carry an increased risk for neuropathy and characterise the type of possible neuropathy. Methods: Electroneuromyographic findings and vibration, thermal, and tactile thresholds of 26 patients with coeliac disease and 23 patients with reflux disease were analysed. Results: Six (23.1 %) coeliac disease patients and one (4.3 %) reflux disease patient showed findings of chronic axonal neuropathy in quantitative needle EMG. In addition, two coeliac disease patients showed findings suggestive for myopathy. There were no significant differences in warm, cold, or vibration thresholds between the groups but means of heat pain thresholds and tactile thresholds were significantly higher in coeliac patients than in controls. Conclusion: An increased occurrence of axonal neuropathy was observed in well treated coeliac disease. This further indicates that neurological manifestations occur even in patients without overt malaborption.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.74.4.490