A transient dysfunction of the neuromuscular junction due to carbendazim intoxication

[...]in animals, especially in rats, adverse effects, including testicular atrophy, infertility, ascendant paralysis, respiratory failure, and muscle cramps due to chronic carbendazim exposure have been well documented. 2-4 Recently, we have treated a 60 year old female farmer who had been affected...

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Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2001-04, Vol.70 (4), p.563-564
Main Authors: ULUDAG, B, TARLACI, S, YUCEYAR, N, ARAC, N
Format: Article
Language:English
Subjects:
Benzimidazoles - poisoning
Biological and medical sciences
Carbamates
Dysphagia
Electric Stimulation
Electromyography
Female
Fungicides, Industrial - poisoning
Humans
Insecticides
Letters to the Editor
Medical sciences
Middle Aged
Neuromuscular Junction - drug effects
Neuromuscular Junction - physiopathology
Neuromuscular Junction Diseases - etiology
Neuromuscular Junction Diseases - physiopathology
Pesticides, fertilizers and other agrochemicals toxicology
Poisoning
Rodents
Toxicology
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Summary:[...]in animals, especially in rats, adverse effects, including testicular atrophy, infertility, ascendant paralysis, respiratory failure, and muscle cramps due to chronic carbendazim exposure have been well documented. 2-4 Recently, we have treated a 60 year old female farmer who had been affected by excessive exposure to carbendazim. Organophosphorus intoxication in the absence of clinical symptoms and signs has been noted after 2 years as a "jitter increasing" by single fibre EMG. 6 The organocarbamate group, by contrast with the organophosphate group, causes reversible binding to acetylcholinesterase.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.70.4.563