Ischaemic heart disease and Cag A strains of Helicobacter pylori in the Caerphilly heart disease study

To look for the presence of the more virulent strains of Helicobacter pylori (H pylori) in men who developed ischaemic heart disease over a 10 year period and in controls. The Caerphilly prospective heart disease study recruited 2512 men aged 45-59 years during 1979-83. Western blot analysis or enzy...

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Published in:British heart journal 2001-11, Vol.86 (5), p.506-509
Main Authors: STONE, A. F. M, RISLEY, P, MARKUS, H. S, BUTLAND, B. K, STRACHAN, D. P, ELWOOD, P. C, MENDALL, M. A
Format: Article
Language:English
Subjects:
Antigens, Bacterial
Bacterial Proteins - blood
Bacterial Proteins - immunology
Biological and medical sciences
Blotting, Western
Cardiology. Vascular system
Cardiovascular Medicine
Case-Control Studies
Coronary heart disease
Enzyme-Linked Immunosorbent Assay
Heart
Helicobacter Infections - complications
Helicobacter Infections - epidemiology
Helicobacter pylori - immunology
Humans
Logistic Models
Male
Medical sciences
Middle Aged
Myocardial Ischemia - epidemiology
Myocardial Ischemia - microbiology
Prospective Studies
Wales - epidemiology
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Summary:To look for the presence of the more virulent strains of Helicobacter pylori (H pylori) in men who developed ischaemic heart disease over a 10 year period and in controls. The Caerphilly prospective heart disease study recruited 2512 men aged 45-59 years during 1979-83. Western blot analysis or enzyme linked immunosorbent assay (ELISA) was performed on serum taken from those who subsequently died of ischaemic heart disease, or developed non-fatal myocardial infarction, to determine H pylori and Cag A status. Similar information was available on age matched controls. During the first decade of the study, 312 men died of ischaemic heart disease or developed non-fatal myocardial infarction. Serum was available from 172 of these (55%). There was no evidence of an association between Cag A seropositivity and incident ischaemic heart disease or ischaemic heart disease mortality, either before or after adjustment for potential confounders (adjusted odds ratios 1.18 (95% confidence interval (CI) 0.76 to 1.85) and 1.13 (95% CI 0.61 to 2.07), respectively). Further, the odds ratios for ischaemic heart disease incidence and ischaemic heart disease mortality by H pylori seropositivity did not appear to depend on the presence or absence of Cag A strains (p = 0.76 and 0.77, respectively). In this cohort of middle aged men, followed over a 10 year period, there is little evidence of an association between Cag A seropositivity and either incident ischaemic heart disease or ischaemic heart disease mortality.
ISSN:1355-6037
0007-0769
1468-201X
DOI:10.1136/heart.86.5.506