Successful treatment of ocular invasive mould infection (fusariosis) with the new antifungal agent voriconazole

[...]a filamentous fungus was diagnosed histopathologically in the excised corneal button (Fig 1 ). Because of the morphological similarities betweenAspergillus,Fusarium, andPseudallescheria boydii on histology these potent causes of keratitis could not be differentiated by this technique alone. Imm...

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Bibliographic Details
Published in:British journal of ophthalmology 2000-08, Vol.84 (8), p.928-928
Main Authors: REIS, ALEXANDER, SUNDMACHER, RAINER, TINTELNOT, KATHRIN, AGOSTINI, HANSJÜRGEN, JENSEN, HENRIK ELVANG, ALTHAUS, CHRISTOPH
Format: Article
Language:English
Subjects:
Adolescent
Antifungal Agents - therapeutic use
Drug dosages
Eye Infections, Fungal - drug therapy
Female
Fusarium - drug effects
Humans
Infections
Letters to the Editor
Pyrimidines - therapeutic use
Triazoles - therapeutic use
Voriconazole
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Summary:[...]a filamentous fungus was diagnosed histopathologically in the excised corneal button (Fig 1 ). Because of the morphological similarities betweenAspergillus,Fusarium, andPseudallescheria boydii on histology these potent causes of keratitis could not be differentiated by this technique alone. Immunohistochemical examination of mycelia containing tissue sections with a panel of specific antifungal antibodies, all Grocott methenamine silver positive hyphae were identified asFusarium species because a strong and uniform reactivity was obtained only with a heterologously absorbed polyclonal antibody raised towards somatic antigens ofFusarium solani. 6 As the antifungal therapy had no effect whatsoever, the regimen was changed to systemic itraconazole (Sempera) 200 mg twice daily (a triazole which is known to be effective against some amphotericin B resistant mould species) for 3 days again with no clinical effect.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.84.8.928d