Magnetic resonance imaging of preterm brain injury

Magnetic resonance imaging (MRI) has proved to be a valuable tool for monitoring development and pathology in the preterm brain. This imaging modality is useful for assessing numerous pathologies including periventricular leukomalacia, intraventricular haemorrhage/germinal layer haemorrhage, and per...

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Bibliographic Details
Published in:	Archives of Disease in Childhood. Fetal and Neonatal Edition 2003-07, Vol.88 (4), p.F269-274
Main Authors:	Counsell, S J, Rutherford, M A, Cowan, F M, Edwards, A D
Format:	Article
Language:	eng
Subjects:	ADC Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy apparent diffusion coefficient Attention Deficit Hyperactivity Disorder Biological and medical sciences Birth weight Brain Injuries - diagnosis Cerebral Infarction - diagnosis conventional spin echo CSE DEHSI diffuse excessive high signal intensity diffusion weighted imaging DWI Emergency and intensive care: neonates and children. Prematurity. Sudden death fast spin echo FSE germinal layer haemorrhage gestational age GLH Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases - diagnosis Intensive care medicine Intracranial Hemorrhages - diagnosis intraventricular haemorrhage IVH magnetic resonance magnetic resonance imaging Magnetic Resonance Imaging - methods Medical sciences MRI NMR Nuclear magnetic resonance periventricular haemorrhagic infarction periventricular leukomalacia PHI Premature birth preterm brain injury PVL Review three dimensional
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Summary:	Magnetic resonance imaging (MRI) has proved to be a valuable tool for monitoring development and pathology in the preterm brain. This imaging modality is useful for assessing numerous pathologies including periventricular leukomalacia, intraventricular haemorrhage/germinal layer haemorrhage, and periventricular haemorrhagic infarction, and can help to predict outcome in these infants. MRI has also allowed the detection of posterior fossa lesions, which are not easily seen with ultrasound. Additionally, and perhaps most relevant, quantitative MR studies have shown differences between the normal appearing preterm brain at term equivalent age and term born infants, confirming that the brain develops differently in the ex utero environment. Further studies using quantifiable MR techniques will improve our understanding of the effects of the ex utero environment, including aspects of neonatal intensive care on the developing brain.
ISSN:	1359-2998 1468-2052