Comparative epidemiology of sudden infant death syndrome and sudden intrauterine unexplained death

Background: Unexplained antepartum stillbirth and sudden infant death syndrome (SIDS) are major contributors to perinatal and infant mortality in the western world. A relation between them has been suggested. As an equivalent of SIDS, only cases validated by post mortem examination are diagnosed as...

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Bibliographic Details
Published in:Archives of disease in childhood. Fetal and neonatal edition 2002-09, Vol.87 (2), p.F118-F121
Main Authors: Frøen, J F, Arnestad, M, Vege, Å, Irgens, L M, Rognum, T O, Saugstad, O D, Stray-Pedersen, B
Format: Article
Language:English
Subjects:
Adult
Age
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Babies
Bacterial infections
Biological and medical sciences
Birth Weight
Confidence intervals
Emergency and intensive care: neonates and children. Prematurity. Sudden death
Epidemiology
Family medical history
Female
Fetal Death - epidemiology
Fetal Growth Retardation - epidemiology
Fetuses
Gestational Age
Health risk assessment
Humans
Hypotheses
Hypoxia
Infant, Newborn
Infections
Intensive care medicine
intrauterine growth restriction
IUGR
Male
Medical sciences
Norway - epidemiology
Obstetrics
Original
Pregnancy
Risk Factors
SIDS
SIUD
Smoking
Still-birth
Stillbirth
Studies
Sudden Infant Death - epidemiology
Sudden infant death syndrome
sudden intrauterine unexplained death
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Summary:Background: Unexplained antepartum stillbirth and sudden infant death syndrome (SIDS) are major contributors to perinatal and infant mortality in the western world. A relation between them has been suggested. As an equivalent of SIDS, only cases validated by post mortem examination are diagnosed as sudden intrauterine unexplained death (SIUD). Objective: To test the hypothesis that SIDS and SIUD have common risk factors. Methods: Registration comprised all stillbirths in Oslo and all infant deaths in Oslo and the neighbouring county, Akershus, Norway during 1986–1995. Seventy six cases of SIUD and 78 of SIDS were found, along with 582 random controls surviving infancy, all singletons. Odds ratios were obtained by multiple logistic regression analysis. Results: Whereas SIUD was associated with high maternal age, overweight/obesity, smoking, and low education, SIDS was associated with low maternal age, smoking, male sex, multiparity, proteinuria during pregnancy, and fundal height exceeding +2 SD. Thus the effects of maternal age were opposite in SIUD and SIDS (adjusted odds ratio 1.39 (95% confidence interval 1.17 to 1.66) per year, p < 0.0005). Heavy smoking, male sex, and a multiparous mother was less likely in SIUD than in SIDS (0.22 (0.06 to 0.83), 0.22 (0.07 to 0.78), and 0.03 (
ISSN:1359-2998
1468-2052
DOI:10.1136/fn.87.2.F118