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Plasma and urinary soluble adhesion molecule expression is increased during first documented acute pyelonephritis
Background: The degree of inflammatory reaction and leucocyte trafficking during acute pyelonephritis has been related to the risk of developing renal parenchymal scarring. Adhesion molecules play a central role in leucocyte recruitment during inflammation. Aims: (1) To determine whether circulating...
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| Published in: | Archives of disease in childhood 2002-03, Vol.86 (3), p.218-221 |
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| container_title | Archives of disease in childhood |
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| creator | Gbadegesin, R A Cotton, S A Coupes, B M Awan, A Brenchley, P E C Webb, N J A |
| description | Background: The degree of inflammatory reaction and leucocyte trafficking during acute pyelonephritis has been related to the risk of developing renal parenchymal scarring. Adhesion molecules play a central role in leucocyte recruitment during inflammation. Aims: (1) To determine whether circulating and urinary concentrations of E-selectin and intercellular adhesion molecule 1 (ICAM-1) were abnormal during first documented acute pyelonephritis; (2) to investigate whether circulating or urinary concentrations were predictive for the development of abnormalities on DMSA imaging. Methods: Plasma and urine samples were collected from 40 children with a first episode of acute pyelonephritis within one week of infection (acute sample) and at six weeks (late sample). Control samples were collected from 21 healthy age matched controls and 18 age matched controls with febrile illness not secondary to urinary tract infection. Results: Plasma and urinary sE-selectin were higher in acute samples (median 176.3 ng/ml and 0.12 ng/mmol respectively) compared with late (97.8 ng/ml and 0.029 ng/mmol) and both control (65.6 ng/ml and 0 ng/mmol) and febrile control (urine 0 ng/mmol) samples. Plasma sICAM-1 was higher in acute samples (428 ng/ml) than controls (365.2 ng/ml), and acute sICAM-1 urine concentrations were higher than febrile control concentrations (3.2 v 0.7 ng/mmol). No correlations were detected between sE-selectin or sICAM-1 and acute or late DMSA scan changes. Conclusion: Plasma and urinary sE-selectin and sICAM-1 are significantly increased during acute pyelonephritis, though no correlation exists between the presence of high plasma or urine concentrations and DMSA scan changes, both during acute infection and six weeks post-infection. |
| doi_str_mv | 10.1136/adc.86.3.218 |
| format | article |
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Adhesion molecules play a central role in leucocyte recruitment during inflammation. Aims: (1) To determine whether circulating and urinary concentrations of E-selectin and intercellular adhesion molecule 1 (ICAM-1) were abnormal during first documented acute pyelonephritis; (2) to investigate whether circulating or urinary concentrations were predictive for the development of abnormalities on DMSA imaging. Methods: Plasma and urine samples were collected from 40 children with a first episode of acute pyelonephritis within one week of infection (acute sample) and at six weeks (late sample). Control samples were collected from 21 healthy age matched controls and 18 age matched controls with febrile illness not secondary to urinary tract infection. Results: Plasma and urinary sE-selectin were higher in acute samples (median 176.3 ng/ml and 0.12 ng/mmol respectively) compared with late (97.8 ng/ml and 0.029 ng/mmol) and both control (65.6 ng/ml and 0 ng/mmol) and febrile control (urine 0 ng/mmol) samples. Plasma sICAM-1 was higher in acute samples (428 ng/ml) than controls (365.2 ng/ml), and acute sICAM-1 urine concentrations were higher than febrile control concentrations (3.2 v 0.7 ng/mmol). No correlations were detected between sE-selectin or sICAM-1 and acute or late DMSA scan changes. Conclusion: Plasma and urinary sE-selectin and sICAM-1 are significantly increased during acute pyelonephritis, though no correlation exists between the presence of high plasma or urine concentrations and DMSA scan changes, both during acute infection and six weeks post-infection.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.86.3.218</identifier><identifier>PMID: 11861252</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Acute Disease ; Biological and medical sciences ; C reactive protein ; C-Reactive Protein - analysis ; Cell adhesion & migration ; Cell adhesion molecules ; Child ; Child, Preschool ; Control Groups ; CRP ; E-selectin ; E-Selectin - metabolism ; Humans ; ICAM ; ICAM-1 ; Infant ; Infections ; intercellular adhesion molecule 1 ; Intercellular Adhesion Molecule-1 - metabolism ; Investigative techniques, diagnostic techniques (general aspects) ; Kidneys ; MCUG ; Medical sciences ; micturating cystourethrogram ; Original ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Patients ; PECAM-1 ; Physiological aspects ; Plasma ; platelet endothelial cell adhesion molecule 1 ; Proteins ; Pyelonephritis ; Pyelonephritis - blood ; Pyelonephritis - diagnostic imaging ; Pyelonephritis - urine ; Radionuclide Imaging ; Rodents ; sICAM-1 ; soluble adhesion molecule ; soluble ICAM-1 ; Studies ; Succimer ; Urinary system ; Urinary tract diseases ; Urine ; Urogenital system ; vesicoureteric reflux ; VUR</subject><ispartof>Archives of disease in childhood, 2002-03, Vol.86 (3), p.218-221</ispartof><rights>Copyright 2002 Archives of Disease in Childhood</rights><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2002 BMJ Publishing Group Ltd.</rights><rights>COPYRIGHT 2002 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2002 Copyright 2002 Archives of Disease in Childhood</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b578t-c5415eaf7b92212b13dad475f3a6e19c2001ffbe2b24469d9da53eb21caae78c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1778077799/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1778077799?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,21406,21422,27957,27958,33646,33647,33912,33913,43768,43915,53827,53829,74578,74754</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13547598$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11861252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gbadegesin, R A</creatorcontrib><creatorcontrib>Cotton, S A</creatorcontrib><creatorcontrib>Coupes, B M</creatorcontrib><creatorcontrib>Awan, A</creatorcontrib><creatorcontrib>Brenchley, P E C</creatorcontrib><creatorcontrib>Webb, N J A</creatorcontrib><title>Plasma and urinary soluble adhesion molecule expression is increased during first documented acute pyelonephritis</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>Background: The degree of inflammatory reaction and leucocyte trafficking during acute pyelonephritis has been related to the risk of developing renal parenchymal scarring. Adhesion molecules play a central role in leucocyte recruitment during inflammation. Aims: (1) To determine whether circulating and urinary concentrations of E-selectin and intercellular adhesion molecule 1 (ICAM-1) were abnormal during first documented acute pyelonephritis; (2) to investigate whether circulating or urinary concentrations were predictive for the development of abnormalities on DMSA imaging. Methods: Plasma and urine samples were collected from 40 children with a first episode of acute pyelonephritis within one week of infection (acute sample) and at six weeks (late sample). Control samples were collected from 21 healthy age matched controls and 18 age matched controls with febrile illness not secondary to urinary tract infection. Results: Plasma and urinary sE-selectin were higher in acute samples (median 176.3 ng/ml and 0.12 ng/mmol respectively) compared with late (97.8 ng/ml and 0.029 ng/mmol) and both control (65.6 ng/ml and 0 ng/mmol) and febrile control (urine 0 ng/mmol) samples. Plasma sICAM-1 was higher in acute samples (428 ng/ml) than controls (365.2 ng/ml), and acute sICAM-1 urine concentrations were higher than febrile control concentrations (3.2 v 0.7 ng/mmol). No correlations were detected between sE-selectin or sICAM-1 and acute or late DMSA scan changes. Conclusion: Plasma and urinary sE-selectin and sICAM-1 are significantly increased during acute pyelonephritis, though no correlation exists between the presence of high plasma or urine concentrations and DMSA scan changes, both during acute infection and six weeks post-infection.</description><subject>Acute Disease</subject><subject>Biological and medical sciences</subject><subject>C reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Cell adhesion & migration</subject><subject>Cell adhesion molecules</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Control Groups</subject><subject>CRP</subject><subject>E-selectin</subject><subject>E-Selectin - metabolism</subject><subject>Humans</subject><subject>ICAM</subject><subject>ICAM-1</subject><subject>Infant</subject><subject>Infections</subject><subject>intercellular adhesion molecule 1</subject><subject>Intercellular Adhesion Molecule-1 - metabolism</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kidneys</subject><subject>MCUG</subject><subject>Medical sciences</subject><subject>micturating cystourethrogram</subject><subject>Original</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Patients</subject><subject>PECAM-1</subject><subject>Physiological aspects</subject><subject>Plasma</subject><subject>platelet endothelial cell adhesion molecule 1</subject><subject>Proteins</subject><subject>Pyelonephritis</subject><subject>Pyelonephritis - blood</subject><subject>Pyelonephritis - diagnostic imaging</subject><subject>Pyelonephritis - urine</subject><subject>Radionuclide Imaging</subject><subject>Rodents</subject><subject>sICAM-1</subject><subject>soluble adhesion molecule</subject><subject>soluble ICAM-1</subject><subject>Studies</subject><subject>Succimer</subject><subject>Urinary system</subject><subject>Urinary tract diseases</subject><subject>Urine</subject><subject>Urogenital system</subject><subject>vesicoureteric reflux</subject><subject>VUR</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>CJNVE</sourceid><recordid>eNp9kt1v0zAUxSMEYmPwxjOKhPh4ICW249h5QZoqKEgVmxCwR-vGvmldnLizE7T997i02gBNPFm6_vnonuOTZU9JOSOE1W_B6JmsZ2xGibyXHZOqlgUtq-p-dlyWJSsaKeVR9ijGTVkSKiV7mB0RImtCOT3OLs8dxB5yGEw-BTtAuM6jd1PrMAezxmj9kPfeoZ7SBK-2AePvmY25HXRAiGhys3u6yjsb4pgbr6cehzHNQU8j5ttrdH7A7TrY0cbH2YMOXMQnh_Mk-_bh_df5x2J5tvg0P10WLRdyLDSvCEfoRNtQSmhLmAFTCd4xqJE0miY3XdcibWlV1Y1pDHCGLSUaAIXU7CR7t9fdTm2PRqeNAji1DbZPJpUHq_6-GexarfxPRQRpSEmSwMuDQPCXE8ZR9TZqdA4G9FNUglSSiEok8Pk_4MZPYUjmkpaQpRCiaRL1ek-twKFK2fkU0dW4gilGJRdLdSqrirOa8oS-uQvV3jlcoUoxzc_uwnXwMQbsbkySUu06olJHlKwVU6kjCX_2ZzC38KEUCXhxACBqcF2AQdt4yzGe_qHZCRV7zsa03s09hB-qFkxw9fn7XF3ML3h9vviidrqv9nzbb_6_4i9TR-Iy</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Gbadegesin, R A</creator><creator>Cotton, S A</creator><creator>Coupes, B M</creator><creator>Awan, A</creator><creator>Brenchley, P E C</creator><creator>Webb, N J A</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20020301</creationdate><title>Plasma and urinary soluble adhesion molecule expression is increased during first documented acute pyelonephritis</title><author>Gbadegesin, R A ; Cotton, S A ; Coupes, B M ; Awan, A ; Brenchley, P E C ; Webb, N J A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b578t-c5415eaf7b92212b13dad475f3a6e19c2001ffbe2b24469d9da53eb21caae78c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acute Disease</topic><topic>Biological and medical sciences</topic><topic>C reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Cell adhesion & migration</topic><topic>Cell adhesion molecules</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Control Groups</topic><topic>CRP</topic><topic>E-selectin</topic><topic>E-Selectin - metabolism</topic><topic>Humans</topic><topic>ICAM</topic><topic>ICAM-1</topic><topic>Infant</topic><topic>Infections</topic><topic>intercellular adhesion molecule 1</topic><topic>Intercellular Adhesion Molecule-1 - metabolism</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Kidneys</topic><topic>MCUG</topic><topic>Medical sciences</topic><topic>micturating cystourethrogram</topic><topic>Original</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Patients</topic><topic>PECAM-1</topic><topic>Physiological aspects</topic><topic>Plasma</topic><topic>platelet endothelial cell adhesion molecule 1</topic><topic>Proteins</topic><topic>Pyelonephritis</topic><topic>Pyelonephritis - blood</topic><topic>Pyelonephritis - diagnostic imaging</topic><topic>Pyelonephritis - urine</topic><topic>Radionuclide Imaging</topic><topic>Rodents</topic><topic>sICAM-1</topic><topic>soluble adhesion molecule</topic><topic>soluble ICAM-1</topic><topic>Studies</topic><topic>Succimer</topic><topic>Urinary system</topic><topic>Urinary tract diseases</topic><topic>Urine</topic><topic>Urogenital system</topic><topic>vesicoureteric reflux</topic><topic>VUR</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gbadegesin, R A</creatorcontrib><creatorcontrib>Cotton, S A</creatorcontrib><creatorcontrib>Coupes, B M</creatorcontrib><creatorcontrib>Awan, A</creatorcontrib><creatorcontrib>Brenchley, P E C</creatorcontrib><creatorcontrib>Webb, N J A</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Education Database (ProQuest)</collection><collection>Family Health Database (Proquest)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gbadegesin, R A</au><au>Cotton, S A</au><au>Coupes, B M</au><au>Awan, A</au><au>Brenchley, P E C</au><au>Webb, N J A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma and urinary soluble adhesion molecule expression is increased during first documented acute pyelonephritis</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>86</volume><issue>3</issue><spage>218</spage><epage>221</epage><pages>218-221</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><notes>Correspondence to:
Dr N J A Webb, Department of Nephrology, Royal Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK;
n.webb@doctors.org.uk</notes><notes>PMID:11861252</notes><notes>href:archdischild-86-218.pdf</notes><notes>istex:5A4CA6BF28D553271014253113AB6B2BDF132E81</notes><notes>ark:/67375/NVC-WCW56PGR-2</notes><notes>local:0860218</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Background: The degree of inflammatory reaction and leucocyte trafficking during acute pyelonephritis has been related to the risk of developing renal parenchymal scarring. Adhesion molecules play a central role in leucocyte recruitment during inflammation. Aims: (1) To determine whether circulating and urinary concentrations of E-selectin and intercellular adhesion molecule 1 (ICAM-1) were abnormal during first documented acute pyelonephritis; (2) to investigate whether circulating or urinary concentrations were predictive for the development of abnormalities on DMSA imaging. Methods: Plasma and urine samples were collected from 40 children with a first episode of acute pyelonephritis within one week of infection (acute sample) and at six weeks (late sample). Control samples were collected from 21 healthy age matched controls and 18 age matched controls with febrile illness not secondary to urinary tract infection. Results: Plasma and urinary sE-selectin were higher in acute samples (median 176.3 ng/ml and 0.12 ng/mmol respectively) compared with late (97.8 ng/ml and 0.029 ng/mmol) and both control (65.6 ng/ml and 0 ng/mmol) and febrile control (urine 0 ng/mmol) samples. Plasma sICAM-1 was higher in acute samples (428 ng/ml) than controls (365.2 ng/ml), and acute sICAM-1 urine concentrations were higher than febrile control concentrations (3.2 v 0.7 ng/mmol). No correlations were detected between sE-selectin or sICAM-1 and acute or late DMSA scan changes. Conclusion: Plasma and urinary sE-selectin and sICAM-1 are significantly increased during acute pyelonephritis, though no correlation exists between the presence of high plasma or urine concentrations and DMSA scan changes, both during acute infection and six weeks post-infection.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>11861252</pmid><doi>10.1136/adc.86.3.218</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of disease in childhood, 2002-03, Vol.86 (3), p.218-221 |
| issn | 0003-9888 1468-2044 |
| language | eng |
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| subjects | Acute Disease Biological and medical sciences C reactive protein C-Reactive Protein - analysis Cell adhesion & migration Cell adhesion molecules Child Child, Preschool Control Groups CRP E-selectin E-Selectin - metabolism Humans ICAM ICAM-1 Infant Infections intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - metabolism Investigative techniques, diagnostic techniques (general aspects) Kidneys MCUG Medical sciences micturating cystourethrogram Original Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Patients PECAM-1 Physiological aspects Plasma platelet endothelial cell adhesion molecule 1 Proteins Pyelonephritis Pyelonephritis - blood Pyelonephritis - diagnostic imaging Pyelonephritis - urine Radionuclide Imaging Rodents sICAM-1 soluble adhesion molecule soluble ICAM-1 Studies Succimer Urinary system Urinary tract diseases Urine Urogenital system vesicoureteric reflux VUR |
| title | Plasma and urinary soluble adhesion molecule expression is increased during first documented acute pyelonephritis |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T02%3A34%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20and%20urinary%20soluble%20adhesion%20molecule%20expression%20is%20increased%20during%20first%20documented%20acute%20pyelonephritis&rft.jtitle=Archives%20of%20disease%20in%20childhood&rft.au=Gbadegesin,%20R%20A&rft.date=2002-03-01&rft.volume=86&rft.issue=3&rft.spage=218&rft.epage=221&rft.pages=218-221&rft.issn=0003-9888&rft.eissn=1468-2044&rft.coden=ADCHAK&rft_id=info:doi/10.1136/adc.86.3.218&rft_dat=%3Cgale_pubme%3EA84453625%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-b578t-c5415eaf7b92212b13dad475f3a6e19c2001ffbe2b24469d9da53eb21caae78c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1778077799&rft_id=info:pmid/11861252&rft_galeid=A84453625&rfr_iscdi=true |