Plasma and urinary soluble adhesion molecule expression is increased during first documented acute pyelonephritis

Background: The degree of inflammatory reaction and leucocyte trafficking during acute pyelonephritis has been related to the risk of developing renal parenchymal scarring. Adhesion molecules play a central role in leucocyte recruitment during inflammation. Aims: (1) To determine whether circulating...

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Bibliographic Details
Published in:Archives of disease in childhood 2002-03, Vol.86 (3), p.218-221
Main Authors: Gbadegesin, R A, Cotton, S A, Coupes, B M, Awan, A, Brenchley, P E C, Webb, N J A
Format: Article
Language:English
Subjects:
Acute Disease
Biological and medical sciences
C reactive protein
C-Reactive Protein - analysis
Cell adhesion & migration
Cell adhesion molecules
Child
Child, Preschool
Control Groups
CRP
E-selectin
E-Selectin - metabolism
Humans
ICAM
ICAM-1
Infant
Infections
intercellular adhesion molecule 1
Intercellular Adhesion Molecule-1 - metabolism
Investigative techniques, diagnostic techniques (general aspects)
Kidneys
MCUG
Medical sciences
micturating cystourethrogram
Original
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Patients
PECAM-1
Physiological aspects
Plasma
platelet endothelial cell adhesion molecule 1
Proteins
Pyelonephritis
Pyelonephritis - blood
Pyelonephritis - diagnostic imaging
Pyelonephritis - urine
Radionuclide Imaging
Rodents
sICAM-1
soluble adhesion molecule
soluble ICAM-1
Studies
Succimer
Urinary system
Urinary tract diseases
Urine
Urogenital system
vesicoureteric reflux
VUR
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Summary:Background: The degree of inflammatory reaction and leucocyte trafficking during acute pyelonephritis has been related to the risk of developing renal parenchymal scarring. Adhesion molecules play a central role in leucocyte recruitment during inflammation. Aims: (1) To determine whether circulating and urinary concentrations of E-selectin and intercellular adhesion molecule 1 (ICAM-1) were abnormal during first documented acute pyelonephritis; (2) to investigate whether circulating or urinary concentrations were predictive for the development of abnormalities on DMSA imaging. Methods: Plasma and urine samples were collected from 40 children with a first episode of acute pyelonephritis within one week of infection (acute sample) and at six weeks (late sample). Control samples were collected from 21 healthy age matched controls and 18 age matched controls with febrile illness not secondary to urinary tract infection. Results: Plasma and urinary sE-selectin were higher in acute samples (median 176.3 ng/ml and 0.12 ng/mmol respectively) compared with late (97.8 ng/ml and 0.029 ng/mmol) and both control (65.6 ng/ml and 0 ng/mmol) and febrile control (urine 0 ng/mmol) samples. Plasma sICAM-1 was higher in acute samples (428 ng/ml) than controls (365.2 ng/ml), and acute sICAM-1 urine concentrations were higher than febrile control concentrations (3.2 v 0.7 ng/mmol). No correlations were detected between sE-selectin or sICAM-1 and acute or late DMSA scan changes. Conclusion: Plasma and urinary sE-selectin and sICAM-1 are significantly increased during acute pyelonephritis, though no correlation exists between the presence of high plasma or urine concentrations and DMSA scan changes, both during acute infection and six weeks post-infection.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.86.3.218