Aldehyde dehydrogenase polymorphism in North American, South American, and Mexican Indian populations

While about 40% of the South American Indian populations (Atacameños, Mapuche, Shuara) were found to be deficient in aldehyde dehydrogenase isozyme I (ALDH2 or E2), preliminary investigations showed very low incidence of isozyme deficiency among North American natives (Sioux, Navajo) and Mexican Ind...

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Bibliographic Details
Published in:American journal of human genetics 1986-03, Vol.38 (3), p.395-399
Main Authors: GOEDDE, H. W, AGARWAL, D. P, HARADA, S, ROTHHAMMER, F, WHITTAKER, J. O, LISKER, R
Format: Article
Language:English
Subjects:
Aldehyde Dehydrogenase - deficiency
Aldehyde Dehydrogenase - genetics
Anthropology. Demography
Biological and medical sciences
Chile
Ecuador
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Hair - enzymology
Human
Human physiology applied to population studies and life conditions. Human ecophysiology
Humans
Indians, North American
Indians, South American
Isoenzymes - deficiency
Isoenzymes - genetics
Medical sciences
Mexico
New Mexico
North Dakota
Polymorphism, Genetic
Population genetics, reproduction patterns
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Summary:While about 40% of the South American Indian populations (Atacameños, Mapuche, Shuara) were found to be deficient in aldehyde dehydrogenase isozyme I (ALDH2 or E2), preliminary investigations showed very low incidence of isozyme deficiency among North American natives (Sioux, Navajo) and Mexican Indians (mestizo). Possible implications of such trait differences on cross-cultural behavioral response to alcohol drinking are discussed.
ISSN:0002-9297
1537-6605