A breast-ovarian cancer susceptibility gene maps to chromosome 17q21

Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the locati...

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Bibliographic Details

Published in:	American journal of human genetics 1993-04, Vol.52 (4), p.736-742
Main Authors:	FEUNTEUN, J, NAROD, S. A, LYNCH, H. T, WATSON, P, CONWAY, T, LYNCH, J, PARBOOSINGH, J, O'CONNELL, P, WHITE, R, LENOIR, G. M
Format:	Article
Language:	eng
Subjects:	Adult Aged BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL VARIABILITY BODY breast Breast Neoplasms - genetics Canada carcinoma chromosome 17 Chromosome Mapping - methods CHROMOSOMES Chromosomes, Human, Pair 17 DISEASES Family Health Female FEMALE GENITALS Gene Expression Genes, Dominant Genetic Linkage GENETIC MAPPING Genetic Markers Genetic Predisposition to Disease GENETIC VARIABILITY Genotype GLANDS GONADS Gynecology. Andrology. Obstetrics HUMAN CHROMOSOME 17 HUMAN CHROMOSOMES Humans Lod Score Male Mammary gland diseases MAMMARY GLANDS man MAPPING Medical sciences Middle Aged NEOPLASMS Neoplastic Syndromes, Hereditary NORTH AMERICA ORGANS 550400 > Genetics Ovarian Neoplasms - genetics OVARIES Pedigree Polymorphism, Genetic Proto-Oncogenes Recombination, Genetic restriction fragment length polymorphism RFLPS Tumors United States
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