EM Changes and Other Toxic Effects of FireMaster BP-6 (Polybrominated Biphenyls) in the Mouse

Groups of Swiss ICR mice were fed 1000 ppm polybrominated biphenyls (FireMaster BP-6) in rodent chow for 4, 8, 11, and 14 days. Control groups were fed standard rodent chow without FireMaster BP-6. Animals were killed at the end of each feeding period and the livers examined by electron microscopy....

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Bibliographic Details
Published in:Environmental health perspectives 1978-04, Vol.23, p.275-281
Main Authors: Corbett, T. H., Simmons, J. L., Kawanishi, H., Endres, J. L.
Format: Article
Language:English
Subjects:
"Workshop on Scientific Aspects of Polybrominated Biphenyls," East Lansing, Michigan, October 24-25, 1978: Steven Aust, Conference Chairman
Adipose tissues
Adrenal glands
Animal Feed
Animals
Biphenyl Compounds - toxicity
Body Weight
Cell Membrane - ultrastructure
Cell Nucleus - ultrastructure
Flame Retardants - toxicity
Hepatocytes
Humans
Infant, Newborn
Liver
Liver - pathology
Liver - ultrastructure
Male
Mice
Microscopy, Electron
Microvilli
Mitochondria, Liver - ultrastructure
Organ Size
Polybrominated biphenyls
Polybrominated Biphenyls - toxicity
Pregnancy
Rodents
Thymus gland
Tissue Distribution
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Summary:Groups of Swiss ICR mice were fed 1000 ppm polybrominated biphenyls (FireMaster BP-6) in rodent chow for 4, 8, 11, and 14 days. Control groups were fed standard rodent chow without FireMaster BP-6. Animals were killed at the end of each feeding period and the livers examined by electron microscopy. EM changes noted were progressive increase in size of hepatocytes, a decrease in rough endoplasmic reticulum, a marked increase in smooth endoplasmic reticulum, mitochondrial degeneration, increased lysosomes, and a decrease in glycogen. In addition, there was increasing proliferation of microvilli in bile canaliculi with increasing feeding times. A group of mice fed 1000 ppm FireMaster BP-6 in rodent chow for 11 days had livers with a mean of 13.93% of total body weight as compared with 6.49% for the control group (P = 0.02). Tissue distribution following ingestion of 100 ppm FireMaster BP-6 for 14 days was studied. Twelve weeks post-feeding, the tissue concentrations of hexabromobiphenyl in order of highest concentration to lowest were as follows: perithymic fat, perirenal fat, adrenal glands, thymus gland, liver and stomach.
ISSN:0091-6765
1552-9924
DOI:10.1289/ehp.7823275