Inhibitor of prostacyclin production in sporadic haemolytic uraemic syndrome

Prostacyclin (PGI2) production was diminished when rat aortic rings were incubated with plasma from 5 of 6 patients with the sporadic form of haemolytic uraemic syndrome but was normal in the presence of plasma from 7 patients with the epidemic form of haemolytic uraemic syndrome or from patients wi...

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Bibliographic Details
Published in:Archives of disease in childhood 1983-09, Vol.58 (9), p.703-708
Main Authors: Levin, M, Elkon, K B, Nokes, T J, Buckle, A M, Dillon, M J, Hardisty, R M, Barratt, T M
Format: Article
Language:English
Subjects:
Adolescent
Anemias. Hemoglobinopathies
Animals
Aorta - metabolism
Biological and medical sciences
Child
Child, Preschool
Creatinine - blood
Diseases of red blood cells
Epoprostenol - biosynthesis
Female
Hematologic and hematopoietic diseases
Hemolytic-Uremic Syndrome - blood
Humans
Infant
Lipids - blood
Male
Medical sciences
Platelet Aggregation
Platelet Count
Prostaglandin Antagonists - blood
Rats
Rats, Inbred Strains
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Summary:Prostacyclin (PGI2) production was diminished when rat aortic rings were incubated with plasma from 5 of 6 patients with the sporadic form of haemolytic uraemic syndrome but was normal in the presence of plasma from 7 patients with the epidemic form of haemolytic uraemic syndrome or from patients with other renal diseases. The reduced PGI2 production was caused by an unstable inhibitor, extractable into polar lipid solvents, in sporadic haemolytic uraemic plasma. These results suggest that there may be at least 2 different pathogenetic mechanisms in epidemic and sporadic haemolytic uraemic syndrome and that the reduced PGI2 production observed in the sporadic type is due to an inhibitor of PGI2 production rather than a deficiency of stimulating factors.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.58.9.703