RecQ helicases: lessons from model organisms

RecQ DNA helicases function during DNA replication and are essential for the maintenance of genome stability. There is increasing evidence that spontaneous genomic instability occurs primarily during DNA replication, and that proteins involved in the S-phase checkpoint are a principal defence agains...

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Bibliographic Details
Published in:Nucleic acids research 2006-09, Vol.34 (15), p.4106-4114
Main Authors: Cobb, Jennifer A, Bjergbaek, Lotte
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - chemistry
Adenosine Triphosphatases - genetics
Adenosine Triphosphatases - metabolism
Adenosine Triphosphatases - physiology
cells
DNA damage
DNA helicases
DNA Helicases - chemistry
DNA Helicases - genetics
DNA Helicases - metabolism
DNA Helicases - physiology
DNA replication
DNA Replication - physiology
exhibitions
Genes, cdc - physiology
genetic stability
genome
Genomic Instability - physiology
Humans
interphase
literature reviews
Mutation
organisms
phenotype
Protein Structure, Tertiary - physiology
RecQ Helicases
S Phase - physiology
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Summary:RecQ DNA helicases function during DNA replication and are essential for the maintenance of genome stability. There is increasing evidence that spontaneous genomic instability occurs primarily during DNA replication, and that proteins involved in the S-phase checkpoint are a principal defence against such instability. Cells that lack functional RecQ helicases exhibit phenotypes consistent with an inability to fully resume replication fork progress after encountering DNA damage or fork arrest. In this review we will concentrate on the various functions of RecQ helicases during S phase in model organisms.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkl557