Computational prediction of microRNA genes in silkworm genome

MicroRNAs （miRNAs） constitute a novel, extensive class of small RNAs （-21 nucleotides）, and play important gene-regulation roles during growth and development in various organisms. Here we conducted a homology search to identify homologs of previously validated miRNAs from silkworm genome. We identi...

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Bibliographic Details
Published in:Journal of Zhejiang University. B. Science 2006-10, Vol.7 (10), p.806-816
Main Authors: Tong, Chuan-zhou, Jin, Yong-feng, Zhang, Yao-zhou
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biotechnology
Bombyx
Bombyx mori
Cluster Analysis
Computational Biology - methods
Drosophila
Drosophila melanogaster
Genetic Complementation Test
Genome
Genomes
MicroRNAs - metabolism
miRNA
Molecular Sequence Data
Multigene Family
Polymorphism, Single Nucleotide
Sequence Homology, Nucleic Acid
Software
Thermodynamics
基因组
计算预报
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Summary:MicroRNAs （miRNAs） constitute a novel, extensive class of small RNAs （-21 nucleotides）, and play important gene-regulation roles during growth and development in various organisms. Here we conducted a homology search to identify homologs of previously validated miRNAs from silkworm genome. We identified 24 potential miRNA genes, and gave each of them a name according to the common criteria. Interestingly, we found that a great number of newly identified miRNAs were conserved in silkworm and Drosophila, and family alignment revealed that miRNA families might possess single nucleotide polymorphisms, miRNA gene clusters and possible functions of complement miRNA pairs are discussed.
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.2006.B0806