Amniotic fluid insulin concentration as a predictor of obesity

Longitudinal correlations were obtained between amniotic fluid insulin concentration at 32 to 38 weeks' gestation and anthropometric characteristics at the age of 6 years in 56 children of diabetic mothers. The prospective studies indicated that at the age of 6 years, as at birth, the greatest...

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Bibliographic Details
Published in:Archives of disease in childhood 1990-10, Vol.65 (10 Spec No), p.1050-1052
Main Authors: Metzger, B E, Silverman, B L, Freinkel, N, Dooley, S L, Ogata, E S, Green, O C
Format: Article
Language:English
Subjects:
Age
Amniocentesis
Amniotic fluid
Amniotic Fluid - metabolism
Body height
Causes of
Child
Children
Complications
Diabetes in pregnancy
Diabetes mellitus
Evaluation
Female
Follow-Up Studies
Gestation
Gestational diabetes
Humans
Insulin
Insulin - metabolism
Obesity
Obesity - diagnosis
Obesity - metabolism
Overweight persons
Pediatrics
Predictive Value of Tests
Pregnancy
Pregnancy Trimester, Third
Prognosis
Prospective Studies
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Summary:Longitudinal correlations were obtained between amniotic fluid insulin concentration at 32 to 38 weeks' gestation and anthropometric characteristics at the age of 6 years in 56 children of diabetic mothers. The prospective studies indicated that at the age of 6 years, as at birth, the greatest increase in weight in relation to height (relative obesity) was seen in children who experienced the greatest exposures to insulin in the uterus (as judged by amniotic fluid insulin concentration). Significant correlations between amniotic fluid insulin and relative obesity at the age of 6 years were found after adjustment for maternal obesity and macrosomia at birth. The highest amniotic fluid insulin values are clustered in the subgroup of 14 children who were obviously obese by the age of 6 years. These findings are consistent with the hypothesis that there is an association between anthropometric development and intrauterine metabolism, and suggest that premature and excessive exposure to insulin during gestation may predispose to obesity in childhood. The amniotic fluid insulin concentration may predict this eventuality.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.65.10_Spec_No.1050