Differential sensitivity of lymphocyte subsets to corticosteroid treatment

Corticosteroid treatment of SJL mice produced a marked decrease in the number of viable lymphocytes obtained 48 hr later from the thymus, spleen and lymph node but no change in peripheral blood. Within the residual lymphocyte population there was a fall in the relative number of splenic B cells with...

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Bibliographic Details
Published in:Immunology 1982-08, Vol.46 (4), p.841-848
Main Authors: Rogers, P, Matossian-Rogers, A
Format: Article
Language:English
Subjects:
Animals
Female
Hydrocortisone - analogs & derivatives
Hydrocortisone - pharmacology
Immunosuppressive Agents - pharmacology
Lymph Nodes - cytology
Lymph Nodes - drug effects
Lymphocytes - classification
Lymphocytes - drug effects
Mice
Mice, Inbred Strains
Spleen - cytology
Spleen - drug effects
Thymus Gland - cytology
Thymus Gland - drug effects
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Summary:Corticosteroid treatment of SJL mice produced a marked decrease in the number of viable lymphocytes obtained 48 hr later from the thymus, spleen and lymph node but no change in peripheral blood. Within the residual lymphocyte population there was a fall in the relative number of splenic B cells with increasing dose; in contrast the proportion of B cells increased in the lymph nodes. The most marked change however was a dose-related increase inthe Lyt-2+ population in all of the lymphoid organs examined including the thymus though, in this organ alone, the lowest dose caused a pronounced reduction in the Lyt-2+ population, since most immature thymocytes are Lyt-2+. These findings support the concept that mature thymocytes have phenotypic identity with peripheral T cells and provide a basis for the immunosuppressive action of corticosteroids.
ISSN:0019-2805
1365-2567