Role of Alveolar Macrophages in Precipitation of Mineral Elements Inhaled As Soluble Aerosols

The lysosomes of several varieties of cells such as the tubular proximal cell of the kidney and the alveolar macrophage have the ability to concentrate and precipitate several elements inhaled in water-soluble form, usually as phosphate. The mechanism involved is attributed to the high acid phosphat...

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Bibliographic Details
Published in:Environmental health perspectives 1992-07, Vol.97, p.145-147
Main Authors: Galle, Pierre, Berry, Jean Pierre, Galle, Christian
Format: Article
Language:English
Subjects:
550200 - Biochemistry
560300 - Chemicals Metabolism & Toxicology
ACID PHOSPHATASE
ACTINIDES
Aerosols
Aluminum - pharmacokinetics
Aluminum Compounds
ANIMAL CELLS
Animals
BASIC BIOLOGICAL SCIENCES
BIOLOGICAL FUNCTIONS
BIOLOGICAL LOCALIZATION
Cerium
Cerium - pharmacokinetics
Chlorides
Chlorides - pharmacokinetics
Chromium - pharmacokinetics
Chromium Compounds
CONNECTIVE TISSUE CELLS
ELEMENTS
ENZYME ACTIVITY
ENZYME INDUCTION
ENZYMES
ESTERASES
GENE REGULATION
HYDROLASES
Intracellular Particle Dissolution
Kidney cells
Lungs
LYSOSOMES
MACROPHAGES
Macrophages, Alveolar - metabolism
Macrophages, Alveolar - ultrastructure
Male
METALS
Microscopy, Electron
Minerals - pharmacokinetics
ORGANIC COMPOUNDS
PHAGOCYTES
Phagosomes - metabolism
Phagosomes - ultrastructure
PHOSPHATASES
Phosphates
PROTEINS
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RARE EARTHS
Rats
Rats, Wistar
Salts
SOMATIC CELLS
Uranyl Nitrate - pharmacokinetics
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Description
Summary:The lysosomes of several varieties of cells such as the tubular proximal cell of the kidney and the alveolar macrophage have the ability to concentrate and precipitate several elements inhaled in water-soluble form, usually as phosphate. The mechanism involved is attributed to the high acid phosphatase activity of lysosomes and can be considered as an in vivo Gomori reaction. Among the elements studied, most of them are chemotoxic or radiotoxic (Cr; group IIIA: Al, Ga, In; rare earths: La, Ce, Tm; actinides: Th, U). In the lung macrophage, this mechanism of intralysosomal concentration and precipitation may prevent the diffusion of these toxic elements through the alveolar membrane.
ISSN:0091-6765
1552-9924
DOI:10.1289/ehp.9297145