Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony

Recent data underscore the importance of intertissue communication in the maintenance of normal glucose homeostasis. Important signals are conveyed by hormones, cytokines, and fuel substrates and are sensed through a variety of cellular mechanisms. The ability of tissues to sense and adapt to change...

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Bibliographic Details
Published in:The Journal of clinical investigation 2006-07, Vol.116 (7), p.1767-1775
Main Authors: Herman, Mark A, Kahn, Barbara B
Format: Article
Language:English
Subjects:
Adipocytes - metabolism
Animals
Biological Transport - physiology
Biomedical research
Carbohydrates
Carbon - chemistry
Carbon - metabolism
Communication
Diabetes
Diabetes Mellitus, Type 2 - metabolism
Energy Metabolism
Exercise
Fatty acids
Glucose
Glucose - metabolism
Homeostasis
Humans
Insulin resistance
Kinases
Medical research
Medicine, Experimental
Metabolism
Metabolites
Musculoskeletal system
Physical fitness
Proteins
Review Series
Signal transduction
Signal Transduction - physiology
Type 2 diabetes
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Summary:Recent data underscore the importance of intertissue communication in the maintenance of normal glucose homeostasis. Important signals are conveyed by hormones, cytokines, and fuel substrates and are sensed through a variety of cellular mechanisms. The ability of tissues to sense and adapt to changes in metabolic status and fuel availability is altered in insulin-resistant states including type 2 diabetes. Here we review the roles of glucose and its metabolites as signaling molecules and the diverse physiologic mechanisms for glucose sensing.
ISSN:0021-9738
1558-8238
DOI:10.1172/jci29027