In vivo efficacy study of the anti-inflammatory properties of Surolan

This study evaluated the anti-inflammatory properties of Surolan with the use of a pinna model of inflammation in 80 mice and a randomized complete block design. Within each of 8 blocks, 10 treatments, consisting of different combinations of the constituents of Surolan with and without the prednisol...

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Bibliographic Details
Published in:Canadian journal of veterinary research 2006-07, Vol.70 (3), p.234-236
Main Authors: Bolinder, A, Cameron, K, Faubert, L, Wilson, J, Aramini, J, Hare, J
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
anti-inflammatory agents
Anti-Inflammatory Agents - therapeutic use
Disease Models, Animal
drug formulations
Ear - pathology
ears
edema
erythema
Female
inflammation
Inflammation - chemically induced
Inflammation - drug therapy
Inflammation - pathology
Inflammation - veterinary
laboratory animals
Mice
Mice, Inbred Strains
miconazole
otitis externa
Otitis Externa - chemically induced
Otitis Externa - drug therapy
Otitis Externa - pathology
Otitis Externa - veterinary
polymyxin B
prednisolone
Prednisolone - analogs & derivatives
Prednisolone - therapeutic use
Random Allocation
Short Communications
Tetradecanoylphorbol Acetate
Treatment Outcome
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Summary:This study evaluated the anti-inflammatory properties of Surolan with the use of a pinna model of inflammation in 80 mice and a randomized complete block design. Within each of 8 blocks, 10 treatments, consisting of different combinations of the constituents of Surolan with and without the prednisolone acetate component, were randomly assigned to the 9-wk-old CD-1 mice. The treatments were administered as a single dose 30 min after pinna inflammation was induced with tetradecanoylphorbol acetate. Ear-skin edema and erythema were assessed and measured 4 and 6 h thereafter. Treatment effects were evaluated with repeated-measures analysis of variance. Inclusion of prednisolone acetate with the Surolan vehicle, either alone or in combination with the nonsteroidal constituents of the suspension, resulted in a significant reduction in mean ear-skin thickness and erythema. The inflammation-reducing properties of prednisolone were not significantly affected by the other components of Surolan.
ISSN:0830-9000