Evidence for a role of developmental genes in the origin of obesity and body fat distribution

Obesity, especially central obesity, is a hereditable trait associated with a high risk for development of diabetes and metabolic disorders. Combined gene expression analysis of adipocyte- and preadipocyte-containing fractions from intraabdominal and subcutaneous adipose tissue of mice revealed coor...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2006-04, Vol.103 (17), p.6676-6681
Main Authors: Gesta, S, Bluher, M, Yamamoto, Y, Norris, A.W, Berndt, J, Kralisch, S, Boucher, J, Lewis, C, Kahn, C.R
Format: Article
Language:English
Subjects:
Adipocytes
Adipocytes - cytology
Adipocytes - metabolism
adipose tissue
Adipose Tissue - growth & development
Adipose Tissue - pathology
Adipose tissues
Adiposity - genetics
Animals
Biological Sciences
Body fat
Body Fat Distribution
Body Mass Index
Cell Differentiation
Developmental genes
Diabetes
differential gene expression
Female
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Developmental
Genes
Glypicans
Heparan Sulfate Proteoglycans - genetics
Homeodomain Proteins - genetics
Humans
In Vitro Techniques
intraabdominal fat
Male
Medicine
Mice
Mice, Inbred C57BL
Obesity
Obesity - etiology
Obesity - genetics
Obesity - pathology
Polymerase Chain Reaction
preadipocytes
Rodents
Species Specificity
stromovascular fraction
subcutaneous fat
T-Box Domain Proteins - genetics
Visceral fat
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Summary:Obesity, especially central obesity, is a hereditable trait associated with a high risk for development of diabetes and metabolic disorders. Combined gene expression analysis of adipocyte- and preadipocyte-containing fractions from intraabdominal and subcutaneous adipose tissue of mice revealed coordinated depot-specific differences in expression of multiple genes involved in embryonic development and pattern specification. These differences were intrinsic and persisted during in vitro culture and differentiation. Similar depot-specific differences in expression of developmental genes were observed in human subcutaneous versus visceral adipose tissue. Furthermore, in humans, several genes exhibited changes in expression that correlated closely with body mass index and/or waist/hip ratio. Together, these data suggest that genetically programmed developmental differences in adipocytes and their precursors in different regions of the body play an important role in obesity, body fat distribution, and potential functional differences between internal and subcutaneous adipose tissue.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0601752103