Relationships among differentiated T-cell subpopulations. V. T-cell dependent mechanism of xenograft rejection and its radioresistant nature

Rat tumours grew progressively in nu/nu mice but not in nu/+ mice, normal AKR mice or sublethally irradiated AKR mice after subcutaneous inoculation. Suppression of tumour growth appeared to depend on radioresistant cytotoxic T cells which were detected in in vivo neutralization tests (Winn's t...

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Bibliographic Details
Published in:Immunology 1979-12, Vol.38 (4), p.773-779
Main Authors: Terasaka, R, Nomoto, K, Himeno, K
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
Antilymphocyte Serum - pharmacology
Ascitic Fluid - immunology
Cell Adhesion
Cell Differentiation
Cell Transformation, Neoplastic
Cytotoxicity, Immunologic
Female
Graft Rejection - radiation effects
Male
Mice
Mice, Inbred AKR
Mice, Inbred BALB C
Mice, Nude
Neoplasm Transplantation
Radiation Protection
Rats
Spleen - radiation effects
T-Lymphocytes - classification
T-Lymphocytes - cytology
T-Lymphocytes - immunology
Transplantation, Heterologous
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Summary:Rat tumours grew progressively in nu/nu mice but not in nu/+ mice, normal AKR mice or sublethally irradiated AKR mice after subcutaneous inoculation. Suppression of tumour growth appeared to depend on radioresistant cytotoxic T cells which were detected in in vivo neutralization tests (Winn's test) with spleen cells of mice immunized with rat lymphocytes or tumour cells 5 days previously. Radioresistant cytotoxic activity was detected by 51Cr-release test in glass-non-adherent peritoneal exudate cells 5 days after intraperitoneal immunization with rat lymphocytes. These results suggested that immune lymphocytes might differentiate to mature cytotoxic cells at the site of direct graft rejection.
ISSN:0019-2805
1365-2567