Evolution of exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes

Comparative analysis of alternative splicing of orthologous genes from fruit flies (Drosophila melanogaster and Drosophila pseudoobscura) and mosquito (Anopheles gambiae) demonstrated that both in the fruit fly genes and in fruit fly-mosquito comparisons, constitutive exons and splicing sites are mo...

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Bibliographic Details
Published in:Genome Research 2006-04, Vol.16 (4), p.505-509
Main Authors: Malko, Dmitry B, Makeev, Vsevolod J, Mironov, Andrey A, Gelfand, Mikhail S
Format: Article
Language:English
Subjects:
Alternative Splicing - genetics
Animals
Anopheles - genetics
Anopheles gambiae
Drosophila melanogaster
Drosophila pseudoobscura
Evolution, Molecular
Exons - genetics
Genes, Insect - genetics
Introns - genetics
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Summary:Comparative analysis of alternative splicing of orthologous genes from fruit flies (Drosophila melanogaster and Drosophila pseudoobscura) and mosquito (Anopheles gambiae) demonstrated that both in the fruit fly genes and in fruit fly-mosquito comparisons, constitutive exons and splicing sites are more conserved than alternative ones. While >97% of constitutive D. melanogaster exons are conserved in D. pseudoobscura, only approximately 80% of alternative exons are conserved. Similarly, 77% of constitutive fruit fly exons are conserved in the mosquito genes, compared with
ISSN:1088-9051
1549-5469
1549-5477
DOI:10.1101/gr.4236606