The Genomes of Recombinant Inbred Lines

Recombinant inbred lines (RILs) can serve as powerful tools for genetic mapping. Recently, members of the Complex Trait Consortium proposed the development of a large panel of eight-way RILs in the mouse, derived from eight genetically diverse parental strains. Such a panel would be a valuable commu...

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Bibliographic Details
Published in:Genetics (Austin) 2005-02, Vol.169 (2), p.1133-1146
Main Author: Broman, Karl W
Format: Article
Language:English
Subjects:
Alleles
Animals
Chromosome Breakage
Chromosome Mapping
Chromosomes
Crossing Over, Genetic
Female
Genetic Linkage
Genome
Genomics
Inbreeding
Investigations
Male
Meiosis
Mice
Mice, Inbred Strains - genetics
Recombination, Genetic
Rodents
X Chromosome
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Summary:Recombinant inbred lines (RILs) can serve as powerful tools for genetic mapping. Recently, members of the Complex Trait Consortium proposed the development of a large panel of eight-way RILs in the mouse, derived from eight genetically diverse parental strains. Such a panel would be a valuable community resource. The use of such eight-way RILs will require a detailed understanding of the relationship between alleles at linked loci on an RI chromosome. We extend the work of Haldane and Waddington on two-way RILs and describe the map expansion, clustering of breakpoints, and other features of the genomes of multiple-strain RILs as a function of the level of crossover interference in meiosis.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1534/genetics.104.035212