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Beta-blockade and growth hormone after burn
To determine whether propranolol and growth hormone (GH) have additive effects to combat burn-induced catabolism. Both GH and propranolol have been attributed anabolic properties after severe trauma and burn. It is conceivable that the two in combination would have additive effects. Fifty-six childr...
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| Published in: | Annals of surgery 2002-10, Vol.236 (4), p.450-457 |
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| Main Authors: | , , , , , |
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| container_end_page | 457 |
| container_issue | 4 |
| container_start_page | 450 |
| container_title | Annals of surgery |
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| creator | Hart, David W Wolf, Steven E Chinkes, David L Lal, Sofia O Ramzy, Peter I Herndon, David N |
| description | To determine whether propranolol and growth hormone (GH) have additive effects to combat burn-induced catabolism.
Both GH and propranolol have been attributed anabolic properties after severe trauma and burn. It is conceivable that the two in combination would have additive effects.
Fifty-six children with more than 40% TBSA burns were randomized to one of four anabolic regimens: untreated control, GH treatment, propranolol treatment, or combination GH plus propranolol therapy. Clinical treatment was identical for all groups. Resting energy expenditure was determined by indirect calorimetry and skeletal muscle protein kinetics were measured using stable amino acid isotope infusions before and after each anabolic regimen.
There were no differences in age, sex, or burn size between groups. Tachycardia and energy expenditure were decreased during propranolol treatment ( |
| doi_str_mv | 10.1097/00000658-200210000-00007 |
| format | article |
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Both GH and propranolol have been attributed anabolic properties after severe trauma and burn. It is conceivable that the two in combination would have additive effects.
Fifty-six children with more than 40% TBSA burns were randomized to one of four anabolic regimens: untreated control, GH treatment, propranolol treatment, or combination GH plus propranolol therapy. Clinical treatment was identical for all groups. Resting energy expenditure was determined by indirect calorimetry and skeletal muscle protein kinetics were measured using stable amino acid isotope infusions before and after each anabolic regimen.
There were no differences in age, sex, or burn size between groups. Tachycardia and energy expenditure were decreased during propranolol treatment ( <.05). The net balance of muscle protein synthesis and breakdown was improved during propranolol and GH plus propranolol treatment ( <.05). There was no significant benefit of GH alone. No additive effect of combination therapy was seen.
Propranolol is a strongly anabolic drug during the early, hypercatabolic period after burn. No synergistic effect between propranolol and GH was identified.</description><identifier>ISSN: 0003-4932</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/00000658-200210000-00007</identifier><identifier>PMID: 12368673</identifier><language>eng</language><publisher>United States</publisher><subject>Adrenergic beta-Antagonists - administration & dosage ; Adrenergic beta-Antagonists - pharmacology ; Adrenergic beta-Antagonists - therapeutic use ; Burns - complications ; Child ; Drug Therapy, Combination ; Energy Metabolism - drug effects ; Female ; Growth Hormone - administration & dosage ; Growth Hormone - pharmacology ; Growth Hormone - therapeutic use ; Humans ; Male ; Metabolic Diseases - drug therapy ; Metabolic Diseases - etiology ; Muscle, Skeletal - drug effects ; Propranolol - administration & dosage ; Propranolol - pharmacology ; Propranolol - therapeutic use ; Scientific Papers of the American Surgical Association ; Trauma Severity Indices</subject><ispartof>Annals of surgery, 2002-10, Vol.236 (4), p.450-457</ispartof><rights>2002 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-de94e12749cb047327c9e65a6c4b0f6b9a49e0959c856bfd0197dae025e9d52c3</citedby><cites>FETCH-LOGICAL-c416t-de94e12749cb047327c9e65a6c4b0f6b9a49e0959c856bfd0197dae025e9d52c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422599/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422599/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12368673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hart, David W</creatorcontrib><creatorcontrib>Wolf, Steven E</creatorcontrib><creatorcontrib>Chinkes, David L</creatorcontrib><creatorcontrib>Lal, Sofia O</creatorcontrib><creatorcontrib>Ramzy, Peter I</creatorcontrib><creatorcontrib>Herndon, David N</creatorcontrib><title>Beta-blockade and growth hormone after burn</title><title>Annals of surgery</title><addtitle>Ann Surg</addtitle><description>To determine whether propranolol and growth hormone (GH) have additive effects to combat burn-induced catabolism.
Both GH and propranolol have been attributed anabolic properties after severe trauma and burn. It is conceivable that the two in combination would have additive effects.
Fifty-six children with more than 40% TBSA burns were randomized to one of four anabolic regimens: untreated control, GH treatment, propranolol treatment, or combination GH plus propranolol therapy. Clinical treatment was identical for all groups. Resting energy expenditure was determined by indirect calorimetry and skeletal muscle protein kinetics were measured using stable amino acid isotope infusions before and after each anabolic regimen.
There were no differences in age, sex, or burn size between groups. Tachycardia and energy expenditure were decreased during propranolol treatment ( <.05). The net balance of muscle protein synthesis and breakdown was improved during propranolol and GH plus propranolol treatment ( <.05). There was no significant benefit of GH alone. No additive effect of combination therapy was seen.
Propranolol is a strongly anabolic drug during the early, hypercatabolic period after burn. No synergistic effect between propranolol and GH was identified.</description><subject>Adrenergic beta-Antagonists - administration & dosage</subject><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Burns - complications</subject><subject>Child</subject><subject>Drug Therapy, Combination</subject><subject>Energy Metabolism - drug effects</subject><subject>Female</subject><subject>Growth Hormone - administration & dosage</subject><subject>Growth Hormone - pharmacology</subject><subject>Growth Hormone - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolic Diseases - drug therapy</subject><subject>Metabolic Diseases - etiology</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Propranolol - administration & dosage</subject><subject>Propranolol - pharmacology</subject><subject>Propranolol - therapeutic use</subject><subject>Scientific Papers of the American Surgical Association</subject><subject>Trauma Severity Indices</subject><issn>0003-4932</issn><issn>1528-1140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpVUE1PwzAMjRCIjcFfQD1xQYEkzUdzQYKJLwmJC5yjNHW3QtuMpAXx72nZGOCDLT_7PVsPoYSSM0q0OidjSJFhRgijY4PHpHbQlAqWYUo52UXTAUox1ymboIMYXwihPCNqH00oS2UmVTpFp1fQWZzX3r3aAhLbFski-I9umSx9aHw7QGUHIcn70B6ivdLWEY42dYaeb66f5nf44fH2fn75gB2nssMFaA6UKa5dTrhKmXIapLDS8ZyUMteWayBaaJcJmZcFoVoVFggToAvBXDpDF2vdVZ83UDhou2BrswpVY8On8bYy_ydttTQL_24oZ0xoPQicbASCf-shdqapooO6ti34PhrFqGRa0GExWy-64GMMUG6PUGJGp82P02br9DekBurx3yd_iRtr0y86XnkA</recordid><startdate>200210</startdate><enddate>200210</enddate><creator>Hart, David W</creator><creator>Wolf, Steven E</creator><creator>Chinkes, David L</creator><creator>Lal, Sofia O</creator><creator>Ramzy, Peter I</creator><creator>Herndon, David N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200210</creationdate><title>Beta-blockade and growth hormone after burn</title><author>Hart, David W ; Wolf, Steven E ; Chinkes, David L ; Lal, Sofia O ; Ramzy, Peter I ; Herndon, David N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-de94e12749cb047327c9e65a6c4b0f6b9a49e0959c856bfd0197dae025e9d52c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adrenergic beta-Antagonists - administration & dosage</topic><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Burns - complications</topic><topic>Child</topic><topic>Drug Therapy, Combination</topic><topic>Energy Metabolism - drug effects</topic><topic>Female</topic><topic>Growth Hormone - administration & dosage</topic><topic>Growth Hormone - pharmacology</topic><topic>Growth Hormone - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolic Diseases - drug therapy</topic><topic>Metabolic Diseases - etiology</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Propranolol - administration & dosage</topic><topic>Propranolol - pharmacology</topic><topic>Propranolol - therapeutic use</topic><topic>Scientific Papers of the American Surgical Association</topic><topic>Trauma Severity Indices</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hart, David W</creatorcontrib><creatorcontrib>Wolf, Steven E</creatorcontrib><creatorcontrib>Chinkes, David L</creatorcontrib><creatorcontrib>Lal, Sofia O</creatorcontrib><creatorcontrib>Ramzy, Peter I</creatorcontrib><creatorcontrib>Herndon, David N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hart, David W</au><au>Wolf, Steven E</au><au>Chinkes, David L</au><au>Lal, Sofia O</au><au>Ramzy, Peter I</au><au>Herndon, David N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beta-blockade and growth hormone after burn</atitle><jtitle>Annals of surgery</jtitle><addtitle>Ann Surg</addtitle><date>2002-10</date><risdate>2002</risdate><volume>236</volume><issue>4</issue><spage>450</spage><epage>457</epage><pages>450-457</pages><issn>0003-4932</issn><eissn>1528-1140</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>ObjectType-News-3</notes><notes>content type line 23</notes><abstract>To determine whether propranolol and growth hormone (GH) have additive effects to combat burn-induced catabolism.
Both GH and propranolol have been attributed anabolic properties after severe trauma and burn. It is conceivable that the two in combination would have additive effects.
Fifty-six children with more than 40% TBSA burns were randomized to one of four anabolic regimens: untreated control, GH treatment, propranolol treatment, or combination GH plus propranolol therapy. Clinical treatment was identical for all groups. Resting energy expenditure was determined by indirect calorimetry and skeletal muscle protein kinetics were measured using stable amino acid isotope infusions before and after each anabolic regimen.
There were no differences in age, sex, or burn size between groups. Tachycardia and energy expenditure were decreased during propranolol treatment ( <.05). The net balance of muscle protein synthesis and breakdown was improved during propranolol and GH plus propranolol treatment ( <.05). There was no significant benefit of GH alone. No additive effect of combination therapy was seen.
Propranolol is a strongly anabolic drug during the early, hypercatabolic period after burn. No synergistic effect between propranolol and GH was identified.</abstract><cop>United States</cop><pmid>12368673</pmid><doi>10.1097/00000658-200210000-00007</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - pharmacology Adrenergic beta-Antagonists - therapeutic use Burns - complications Child Drug Therapy, Combination Energy Metabolism - drug effects Female Growth Hormone - administration & dosage Growth Hormone - pharmacology Growth Hormone - therapeutic use Humans Male Metabolic Diseases - drug therapy Metabolic Diseases - etiology Muscle, Skeletal - drug effects Propranolol - administration & dosage Propranolol - pharmacology Propranolol - therapeutic use Scientific Papers of the American Surgical Association Trauma Severity Indices |
| title | Beta-blockade and growth hormone after burn |
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