Beta-blockade and growth hormone after burn

To determine whether propranolol and growth hormone (GH) have additive effects to combat burn-induced catabolism. Both GH and propranolol have been attributed anabolic properties after severe trauma and burn. It is conceivable that the two in combination would have additive effects. Fifty-six childr...

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Bibliographic Details
Published in:Annals of surgery 2002-10, Vol.236 (4), p.450-457
Main Authors: Hart, David W, Wolf, Steven E, Chinkes, David L, Lal, Sofia O, Ramzy, Peter I, Herndon, David N
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - administration & dosage
Adrenergic beta-Antagonists - pharmacology
Adrenergic beta-Antagonists - therapeutic use
Burns - complications
Child
Drug Therapy, Combination
Energy Metabolism - drug effects
Female
Growth Hormone - administration & dosage
Growth Hormone - pharmacology
Growth Hormone - therapeutic use
Humans
Male
Metabolic Diseases - drug therapy
Metabolic Diseases - etiology
Muscle, Skeletal - drug effects
Propranolol - administration & dosage
Propranolol - pharmacology
Propranolol - therapeutic use
Scientific Papers of the American Surgical Association
Trauma Severity Indices
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Summary:To determine whether propranolol and growth hormone (GH) have additive effects to combat burn-induced catabolism. Both GH and propranolol have been attributed anabolic properties after severe trauma and burn. It is conceivable that the two in combination would have additive effects. Fifty-six children with more than 40% TBSA burns were randomized to one of four anabolic regimens: untreated control, GH treatment, propranolol treatment, or combination GH plus propranolol therapy. Clinical treatment was identical for all groups. Resting energy expenditure was determined by indirect calorimetry and skeletal muscle protein kinetics were measured using stable amino acid isotope infusions before and after each anabolic regimen. There were no differences in age, sex, or burn size between groups. Tachycardia and energy expenditure were decreased during propranolol treatment (
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-200210000-00007